tissue-engineered biomaterials have existed approximately 40 years as simple biomimetic structures. replacement of human tissue with new tissue can be accomplished by generating replacements outside of the body or in situ in the body. in each case, the key elements are described as the tissue engineering triad of scaffolds, cells, and signals. scaffolds can be produced synthetically or derived ...

introduction: adult stem cells are the group of cells which conserve their nature in tissues and organs among other cells. in recent years, the researchers reported the existence of stem cells on the bulge of hair follicles near to the smooth muscle. it is possible to differentiate these stem cells to neural cells by induction of shh, fgf, and ra factors. because of existence of these factors i...

introduction: mechanical stimulation of human mesenchymal stem cells has demonstrated changes in many cell behaviours such as adhesion, migration, growth and differentiation through mechanotransductive pathways. these include experiments on effect of nanotopography 1, shear stress, stiffness of extracellular matrix 2, strain, stress and acoustic wave energy 3 on cells. in this research we were ...

cancer stem cells (cscs) have been identified as rare cellular populations in many cancers, including leukemia and solid tumors. this minor subpopulation of cancerous cells is immortal tumor-initiating cells which thought to be responsible for cancer initiation, progression, metastasis, recurrence and drug/radiation resistance. low proliferative rate, high self-renewing capacity, differentiatio...

introduction: the use of cord stem cells, as a cell source for bone marrow reconstruction in patient under hematopoietic stem cell transplantation is enhancing. the amount of cd34+cells collected from cord blood compared to peripheral blood and bone marrow are less, but their collectionprocesure is easier. delay in freezing has negative effect on cells surveillance and reduce their ability in t...

the old wishes of people were to regenerate lost tissues of periodontium that this fact is achieved by gen and cell therapy .periodontal disease is a chronic inflammation around the tooth by microbes that causes destruction of supporting structure of tissue of tooth such as alveolar bone, cementum and periodontal ligament. for treatment of periodontal diseases we can use the biomaterials which ...

background  spermatogonial stem cells (sscs) are the foundation of spermatogenesis. sound wave especially low intensity ultrasound (lius) can be effective on increasing the number of cells. in this study we investigated the effect of lius stimulation on mouse sscs proliferation and colonization. methods: isolated sscs from neonate mice cultured in dmem culture medium with 10% fetal bovine serum...

cell therapy is a modern approach in the treatment of most of the diseases which uses stem cells and it has been recently developed rapidly. cell therapy has shown satisfactory results in this way. our country, iran, has played an important role in the development of this new method and the results of stem cell treatment used for the most of the diseases were successful. the results have led to...

background  to report normal variations of the limbal structures using in vivo laser scanning confocal microscopy. methods: this was a retrospective study of fourteen eyes from 11 healthy individuals. confocal imaging of cornea and limbus was performed using heidelberg retina tomograph iii rostock corneal module. results: the typical structure of the palisades of vogt (pov) was detected in 57% ...

introduction perforation of maxillary sinus mucous membrane is of the most prevalent complication during open sinus lift surgery. moreover, such complication can usually be managed by an absorbable membrane. as far as absorbable membranes are concerned, decellularized maxillary sinus mucous membranes, which is an extracellular matrix, can be used as a biologic scaffold and insulating membrane i...