Primary meningeal rhabdomyosarcoma is a rare primary brain malignancy, with scant case reports. While most reports of primary intracranial rhabdomyosarcoma occur in pediatric patients, a handful of cases in adult patients have been reported in the medical literature. We report the case of a 44-year-old male who developed primary meningeal rhabdomyosarcoma. After developing episodes of right low...

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the growth of several cancer cell lines. The aim of this study is to compare the cytotoxic effect of aspirin with diclofenac on the growth of HeLa cell, mammary cell carcinoma, rhabdomyosarcoma and fibroblast cell lines in the culture media. The cells are cultured in RPMI-1640 culture media supplemented with 5% fetal calf serum and antibiot...

Gene expression profiling has revealed that the gene coding for cannabinoid receptor 1 (CB1) is highly up-regulated in rhabdomyosarcoma biopsies bearing the typical chromosomal translocations PAX3/FKHR or PAX7/FKHR. Because cannabinoid receptor agonists are capable of reducing proliferation and inducing apoptosis in diverse cancer cells such as glioma, breast cancer, and melanoma, we evaluated ...

BACKGROUND Patupilone (EPO906) is a microtubule stabilizer with a potent antitumor effect. Integrin αVβ3-binding (RGD) liposomes were loaded with EPO906, and their antitumor efficacy was evaluated in two pediatric tumor models, ie, neuroblastoma and rhabdomyosarcoma. METHODS Integrin αVβ3 gene expression, RGD-liposome cellular association, and the effect of EPO906 and liposomal formulations o...

background: rhabdomyosarcoma is a rare malignant soft tissue sarcoma and the most common sarcoma of childhood. the purpose of this study was to investigate the distribution of age and sex of patients, pathological subtypes and to determine the role of staging and classification of rms on treatment outcome. materials and methods: this retrospective study included patients who diagnosed with rms ...

the hypertension is divided into two types: primary and secondary. the secondary type, is particularly due to renal and arterial origin and is mostly seen. in children the secondary hypertension caused by malignancies is rare. this is a case of abdominal rhabdomyosarcoma with malignant hypertension.

1. Skapek SX, Ferrari A, Gupta AA, et al. Rhabdomyosarcoma. Nat Rev Dis Primers. 2019; 5(1): https://doi.org/10.103 /s41572-018-0051-2. Google Scholar

BACKGROUND Congenital alveolar rhabdomyosarcoma is an extremely uncommon and invariably fatal tumor with the current therapy. Less than 25% of patients present with evidence of cutaneous metastasis. CASE PRESENTATION We report a case of congenital alveolar rhabdomyosarcoma in an 18-month-old male who presented with a progressively increasing mass lesion in the left post-auricular region since...

Rhabdomyosarcoma is extremely rare in adults, but is the most common extra cranial solid tumor in children. Rhabdomyosarcoma in adults is a heterogeneous disease, with different form of presentation, histology, and prognosis and with difficulty in its treatment due to the rarity of the disease. Here we briefly review the literature on adult rhabdomyosarcoma and present the case of a 39-year-old...

Rhabdomyosarcoma, the most common soft tissue malignancy of childhood, is a morphologically variable tumor defined by its phenotype of skeletal muscle differentiation. The diagnosis of rhabdomyosarcoma often relies in part on the identification of myogenic gene expression using immunohistochemical or molecular techniques. However, these techniques show imperfect sensitivity and specificity, par...