We present a case of therapy-related myelodyspastic syndrome in which the t(3;8)(q26;q24) translocation appeared, even though no chromosomal abnormalities were found at the initial diagnosis of acute myeloid leukemia. To the best of our knowledge, there have only been around 20 reported cases of myeloid malignancies involving t(3;8)(q26;q24). We discuss the characteristics of t(3;8)(q26;q24) al...

We identified a fusion between ETV6 on 12p13 and MDS1/EVI1 on 3q26 in a t(3;12)(q26;p13) found in two cases of myeloproliferative disorder. The resulting chimeric transcript consists of the first two exons of ETV6 fused to MDS1 sequences, which in turn is fused to the second exon of the EVI1 gene. It has recently been reported that MDS1 can be expressed in normal tissues both as a single gene a...

We identifieda fusionbetweenETV6 on l2pl3 and MDSJIEVIJ on 3q26 in a t(3;12)(q26;p13)found in two casesof myeloproliferative disor. der. The resultingchimerictranscriptconsistsof the first two exonsof ETV6 fused to MDSJ sequences, which in turn is fused to the second exon of the EVIl gene. It has recently been reported that MDS1 can be expressed in normal tissues both as a single gene and fused...