Lenvatinib is a multityrosine kinase inhibitor that inhibits vascular endothelial growth factor receptors, and is being developed as an anticancer drug. P450s are involved in one of the elimination pathways of lenvatinib, and mono-oxidized metabolites, such as N-oxide (M3) and desmethylated metabolite (M2), form in rats, dogs, monkeys, and humans. Meanwhile, two other oxidative metabolites are ...

Over the past two decades plenty of resonant and quasi-resonant converters have been developed and proposed as an answer to the difficulties raised by square-wave converters, especially those related to their parasitic elements. The basic idea is to put these parasitics in use. The core of both classes of converters is a tank circuit. Unlike resonant converters, where it takes part actively in ...

Cytochrome P450 monooxygenases (P450s), which are well-known drug-metabolizing enzymes, are thought to play a signal transduction role in m opioid analgesia and may serve as high-affinity H-cimetidine (HCIM) binding sites in the brain. HCIM binding sites may also be related to opioid or nonopioid analgesia. However, of the more than 100 murine P450 enzymes, the specific isoform(s) responsible f...

Cytochrome P450 monooxygenases (P450s), which are well-known drug-metabolizing enzymes, are thought to play a signal transduction role in m opioid analgesia and may serve as high-affinity H-cimetidine (HCIM) binding sites in the brain. HCIM binding sites may also be related to opioid or nonopioid analgesia. However, of the more than 100 murine P450 enzymes, the specific isoform(s) responsible f...

Cytochrome P450 monooxygenases (P450s), which are well-known drug-metabolizing enzymes, are thought to play a signal transduction role in m opioid analgesia and may serve as high-affinity H-cimetidine (HCIM) binding sites in the brain. HCIM binding sites may also be related to opioid or nonopioid analgesia. However, of the more than 100 murine P450 enzymes, the specific isoform(s) responsible f...

Cytochrome P450 monooxygenases (P450s), which are well-known drug-metabolizing enzymes, are thought to play a signal transduction role in m opioid analgesia and may serve as high-affinity H-cimetidine (HCIM) binding sites in the brain. HCIM binding sites may also be related to opioid or nonopioid analgesia. However, of the more than 100 murine P450 enzymes, the specific isoform(s) responsible f...

Cytochrome P450 monooxygenases (P450s), which are well-known drug-metabolizing enzymes, are thought to play a signal transduction role in m opioid analgesia and may serve as high-affinity H-cimetidine (HCIM) binding sites in the brain. HCIM binding sites may also be related to opioid or nonopioid analgesia. However, of the more than 100 murine P450 enzymes, the specific isoform(s) responsible f...

Regulat ion of the immune system has been shown (1) to result from complex interactions among subsets of lymphocytes and other cells. Some of these interactions are defined as genetically restricted when the effective interaction requires a certain identity among the cells involved. The genetic restrictions reflect the specificity of the T lymphocyte 's receptors and are of two types: (a) As or...