The activity of uridine kinase in rat liver is markedly enhanced following the intraperitoneal administration of 5azacytidine by a process independent of adrenal secretion. The enhancement of enzyme activity is dose-dependent and is maximal at 24 to 28 hours following the administration of the analogue. The increase of uridine kinase in the liver is unaffected by a number of compounds interferi...

The activity of uridine kinase in rat liver is markedly enhanced following the intraperitoneal administration of 5azacytidine by a process independent of adrenal secretion. The enhancement of enzyme activity is dose-dependent and is maximal at 24 to 28 hours following the administration of the analogue. The increase of uridine kinase in the liver is unaffected by a number of compounds interferi...

Pyrazofurin(P9, which is an inhibitorof orotidybate decarboxylase (the conversion of orotidine 5'-monophos phate to uridine 5-monophosphate) results in marked reductions of intracellular levels of uridine triphosphate and cytidine5'-triphosphate.These triphosphateribonu cleotides are known inhibitors of uridine-cytidine kinase. Exogenousuridineis rapidlyphosphorylatedto uridine5'monophosphateby...

Dear Editor, Patient-specific induced pluripotent stem (iPS) cells, generated from somatic cells of disease-affected individuals, hold a tremendous potential for studying disease mechanisms and for drug screening approaches using cell types previously not available (Yamanaka, 2008). Fragile-X (FX) syndrome belongs to the autism spectrum disorders, and is the most common cause of inherited menta...

Exotoxin from B. thuringiensis was purified by chromatography and its structure was determined by means of chemical and physical methods. The formula of the substance as given above indicates that the exotoxin possesses between ribose and glucose an unusual ether bond which up to now has not been found in Nature. The study of the mechanism of action of the exotoxin shows that it competes with A...

4th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences Cardiovascular Repair and Regeneration: Structural and Molecular Approaches in the Cellular Era July 30–August 2, 2007 Keystone Conference Center Keystone, CO Sponsored by the American Heart Association Councils on Basic Cardiovascular Sciences and Clinical Cardiology and the American Heart Associati...