Background & Objective:  The incidence of biofilm-related infections caused by Candida albicans has increased dramatically. C. albicans biofilm-related infections are more resistant to antifungal medications. This work was an attempt to examine inhibitory effects of fluconazole in combination with amphotericin B on fluconazole-resistant C. albicans biofilm.  Materials & Methods:  Fluconazole-...

fluconazole is commonly used both to prevent and to treat invasive neonatal candida albicans infection. this drug is a potent, selective, triazole inhibitor of the fungal enzymes involved in ergosterol synthesis. it is largely excreted unchanged in the urine. in infants with a birth weight <1,500 grams, fungal infection is approximately 3% to 4%. up to 30% of infants with invasive candidiasis d...

conclusions the findings show fluconazole -resistance in c. albicans isolates with overexpression of pir1p. results in the 52 isolates, 49 (94%) were resistant to fluconazole. overexpression of pir1 gene was detected in 47 (96%) fluconazole-resistant c. albicans isolates. patients and methods a total of 52l vaginal samples were obtained from the females with c. albicans vaginitis. the azole sus...

conclusions totally, our results showed nanosilver caused an increase of at least nine-fold in inhibitory effect of fluconazole. materials and methods we studied effect of fluconazole, nanosilver, and their combination on 20 fluconazole-resistant c. albicans from two centers and one standard sample (atcc10261) by minimal inhibitory concentration (mic) method. background opportunistic fungi caus...

BACKGROUND In human immunodeficiency virus (HIV)-infected patients, fluconazole prophylaxis is associated with reductions in the rate of fungal infection. However, concerns exist with regard to the use of fluconazole prophylaxis and the risk of development of fluconazole treatment-refractory infections. METHODS We performed a randomized, open-label trial that compared oral fluconazole given c...

Mutations in the ergosterol biosynthesis gene 11 (ERG11) of Candida albicans have been frequently reported in fluconazole-resistant clinical isolates. Exploring the mutations and their effect could provide new insights into the underlying mechanism of fluconazole resistance.  Erg11p_Threonine285Alanine (Erg11p_THR285ALA), Erg11p_Leucine321Phenylalanine (Erg11p_LEU321PHE) and Erg11p_Serine457Pro...

Background. In human immunodeficiency virus (HIV)–infected patients, fluconazole prophylaxis is associated with reductions in the rate of fungal infection. However, concerns exist with regard to the use of fluconazole prophylaxis and the risk of development of fluconazole treatment–refractory infections. Methods. We performed a randomized, open-label trial that compared oral fluconazole given c...

Recurrent vulvovaginal candidiasis (RVVC) is seen in 5% of women with Candida vaginitis. Use of fluconazole as prophylactic treatment has been suggested for RVVC. The aim of the present study was to evaluate the efficacy of fluconazole suppressive therapy in RVVC patients, as a randomized, placebo-controlled, double-blind prophylactic study. Among the 330 women with acute symptomatic vulvovagin...

BACKGROUND Fluconazole is recommended as first-line treatment in invasive candidiasis in children and infants. Although timely achievement of adequate exposure of fluconazole improves outcome, therapeutic drug monitoring is currently not recommended. METHODS We conducted a retrospective study of critically ill children treated with fluconazole from January 2007 to October 2013 and for whom fl...

Recurrent vulvovaginal candidiasis (RVVC) is seen in 5% of women with Candida vaginitis. Use of fluconazole as prophylactic treatment has been suggested for RVVC. The aim of the present study was to evaluate the efficacy of fluconazole suppressive therapy in RVVC patients, as a randomized, placebo-controlled, double-blind prophylactic study. Among the 330 women with acute symptomatic vulvovagin...