implantation failure is the most frequent cause of pregnancy loss in couples who try to conceive, either in a natural way or using assisted reproductive techniques (art). identify the precise mechanisms of implantation failure can lead to identify couples at risk and also providing appropriate therapeutic options to affected couples. despite the high prevalence of this disorder, a few causing f...

Background: The process of implantation involves the interaction of the human embryo and the uterine epithelium. Failure of implantation is a major reason for infertility in women and the inability to achieve endometrial receptivity is responsible for much of the failure of reproductive technologies. Management of repeated implantation failure despite transfer of good-quality embryos still rema...

objective: several studies have shown the improving effect of heparin on the outcomes of art. moreover, it has been reported that adding heparin in non-thrombophilia patients with rif is useful.the aim of this study was to evaluate the beneficial effects of heparin on art outcomes in women with history of recurrent implantation failure (rif) and without history of congenital or acquired thrombo...

Implantation failure is the most frequent cause of pregnancy loss in couples who try to conceive, either in a natural way or using assisted reproductive techniques (ART). Identify the precise mechanisms of implantation failure can lead to identify couples at risk and also providing appropriate therapeutic options to affected couples. Despite the high prevalence of this disorder, a few causing f...

Recurrent implantation failure (RIF) has many definitions, but usually authors consider RIF, the failure to achieve a pregnancy fallowing 2-6 IVF cycles in which more than 10 high grade embryos were transferred to the uterus. There are a lot of causes for RIF but two main causes of that are related to embryo and endometrium. Chromosomal abnormalities, zona hardening and problems in culture medi...

background: repeated implantation failure (rif) is defined as pregnancy failure after two to six times with at least ten high grade embryo transfer to uterus. a variety of causes have been anticipated for rif, including anatomical, autoimmune, genetics, endocrine and thrombotic anomalies. factors responsible for rif have important implication regarding treatment however in many couples a perfec...

Abstract Background Polymorphism A1298C of the methylenetetrahydrofolate-reductase (MTHFR) gene has been implicated in spontaneous abortion. In this study, we determined the allele and genotype frequencies of this polymorphism in recurrent spontaneous abortion (RSA) and implantation failure after in vitro fertilization (IVF). Materials and Methods We performed a case–control study on 60 wom...

objective: repeated implantation failure (rif) is a condition in which the embryos implantation decreases in the endometrium. so, our aim was to evaluate the effect of local endometrial injury on embryo transfer results. materials and methods: in this simple randomized clinical trial (rct), a total of 120 patients were selected. the participants were less than 40 years old, and they are in thei...

background: implantation failure of blastocyst is one of the main reasons of failure to become pregnancy following use of assisted reproductive techniques. hla-g, one of the non-classic hla subtypes, seems to have a vital role in neutralizing of mother immune system. according to importance of ins/del polymorphism of hla-g in regulation of hla-g expression, it seems that this polymorphism has a...

The success of reproduction, although gradually increasing over the years, many couples also had been left frustrated following repeated failed attempts. Clinicians who treated unsuccessful couples often face a challenge. The probable causes of repeated IVF failures classified as: reduced endometrial receptivity, embryonic defects or multifactorial causes. Intrauterine and endometrial integrity...