background: respiratory syncytical virus infection is the most common cause of bronchiolitis and viral pneumonia in infancy. objective: to investigate the placental transfer of rsv-specific igg in iranian mothers. methods: the antibodies were measured in sera of 146 mother/newborn pairs using a commercially available indirect enzyme linked immunosorbent assay (elisa). the studied subjects were ...

Background: Respiratory Syncytical virus infection is the most common cause of bronchiolitis and viral pneumonia in infancy. Objective: To investigate the placental transfer of RSV-specific IgG in Iranian mothers. Methods: The antibodies were measured in sera of 146 mother/newborn pairs using a commercially available indirect Enzyme Linked Immunosorbent Assay (ELISA). The studied subjects were ...

Two cases are reported in which amiodarone was administered during pregnancy for longer periods than has been reported previously. Limited placental transfer of amiodarone and its desethyl metabolite was observed in both cases. A normal child resulted from each pregnancy despite, in one case, amiodarone therapy throughout the entire pregnancy. However, caution is urged in the use of amiodarone ...

Two hundred thirteen mother-baby pairs in The Gambia were studied to determine the influence of placental malaria infection and maternal hypergammaglobulinemia on transplacental antibody transfer. Antibody transfer for herpes simplex virus 1 (HSV-1), respiratory syncytial virus (RSV), and varicella-zoster virus (VZV) was significantly reduced by placental malaria infection by 69%, 58%, and 55%,...

PURPOSE Sufentanil, a lipophilic opioid, is used to provide analgesia for labour and Caesarean section, but may cause neonatal depression. Factors affecting placental transfer of sufentanil were investigated using human placentas. STUDY DESIGN Transfer and uptake of sufentanil by the human placenta were studied using a single pass (open) in vitro perfusion model. The effects of change in sufe...

The placental perfusion model and a newly developed complementary computational model are reviewed. Examples are provided, where the computational model can be applied to adjust drug pharmacokinetic data obtained from the perfusion model to more closely resemble the in vivo placental transfer of therapeutic agents. After modelling the data, placental perfusion experiments can be used to predict...