نتایج جستجو برای: RBP4

تعداد نتایج: 415  

Journal: :Molecular and cellular biology 2012
Julie Norseen Tetsuya Hosooka Ann Hammarstedt Mark M Yore Shashi Kant Pratik Aryal Urban A Kiernan David A Phillips Hiroshi Maruyama Bettina J Kraus Anny Usheva Roger J Davis Ulf Smith Barbara B Kahn

Retinol-binding protein 4 (RBP4), the sole retinol transporter in blood, is secreted from adipocytes and liver. Serum RBP4 levels correlate highly with insulin resistance, other metabolic syndrome factors, and cardiovascular disease. Elevated serum RBP4 causes insulin resistance, but the molecular mechanisms are unknown. Here we show that RBP4 induces expression of proinflammatory cytokines in ...

2017
Spencer J. Thompson Ashot Sargsyan Seung-Ah Lee Jason J. Yuen Jinjin Cai Rana Smalling Norbert Ghyselinck Manuel Mark William S. Blaner Timothy E. Graham

RBP4 is produced mainly by hepatocytes. In type 2 diabetes and obesity, circulating RBP4 is increased and may act systemically to cause insulin resistance and glucose intolerance. Observations that adipocyte RBP4 mRNA increases in parallel with circulating RBP4 in these conditions, whereas liver RBP4 mRNA does not, led to a widely held hypothesis that elevated circulating RBP4 is a direct resul...

2017
Mei Du Ashley Martin Franklin Hays Jennifer Johnson Rafal A. Farjo Krysten M. Farjo

PURPOSE Elevation of serum retinol-binding protein 4 (RBP4) induces inflammation in primary human retinal microvascular endothelial cells (HRECs) via a retinol-independent mechanism; thus, it may play a causative role in the development and progression of vascular lesions in diabetic retinopathy (DR). Since HRECs do not express the classical RBP4 receptor, stimulated by retinoic acid gene 6 (ST...

2013
Noriyasu SASAKI Miwa ISHIBASHI Satoshi SOETA

Retinol-binding protein 4 (RBP4) is a specific transporter of retinol and was recently identified as an adipokine potentially involved in type 2 diabetes in humans and rodents. However, the function and structure of feline RBP4 have not been reported. In this study, we describe the molecular cloning and expression analysis of feline RBP4. The complete feline RBP4 cDNA encodes a precursor protei...

Journal: :American journal of physiology. Endocrinology and metabolism 2008
Nimesh Mody Timothy E Graham Yuki Tsuji Qin Yang Barbara B Kahn

Serum retinol-binding protein (RBP4) is secreted by liver and adipocytes and is implicated in systemic insulin resistance in rodents and humans. RBP4 normally binds to the larger transthyretin (TTR) homotetramer, forming a protein complex that reduces renal clearance of RBP4. To determine whether alterations in RBP4-TTR binding contribute to elevated plasma RBP4 levels in insulin-resistant stat...

Journal: :Diabetes 2008
José Manuel Fernández-Real José María Moreno Wifredo Ricart

OBJECTIVES The mechanisms behind the association between retinol-binding protein-4 (RBP4) and insulin resistance are not well understood. An interaction between iron and vitamin A status, of which RBP4 is a surrogate, has long been recognized. We hypothesized that iron-associated insulin resistance could be behind the impaired insulin action caused by RBP4. RESEARCH DESIGN AND METHODS Serum f...

2012
Gary Huang Dan Wang Unab I Khan Irfan Zeb JoAnn E Manson Virginia Miller Howard N Hodis Matthew J Budoff George R Merriam Mitchell S Harman Eliot A Brinton Marcelle I Cedars Yali Su Rogerio A Lobo Frederick Naftolin Nanette Santoro Hugh S Taylor Rachel P Wildman

BACKGROUND The published literature regarding the relationships between retinol-binding protein 4 (RBP4) and cardiometabolic risk factors and subclinical atherosclerosis is conflicting, likely due, in part, to limitations of frequently used RBP4 assays. Prior large studies have not utilized the gold-standard western blot analysis of RBP4 levels. METHODS Full-length serum RBP4 levels were meas...

2010
Alexander Koch Ralf Weiskirchen Edouard Sanson Henning W Zimmermann Sebastian Voigt Hanna Dückers Christian Trautwein Frank Tacke

INTRODUCTION Hyperglycemia and insulin resistance are well-known features of critical illness and impact the mortality rate, especially in sepsis. Retinol binding protein 4 (RBP4) promotes insulin resistance in mice and is systemically elevated in patients with obesity and type 2 diabetes. We investigated the potential role of RBP4 in critically ill patients. METHODS We conducted a prospectiv...

2017
Fabrizio Grosjean Pasquale Esposito Rosario Maccarrone Carmelo Libetta Antonio Dal Canton Teresa Rampino

Introduction Retinol Binding Protein 4 (RBP4) is mainly excreted by the kidney and plays a pivotal role in insulin resistance (IR). In our study, we evaluated the association between RBP4 and IR in hemodialysis subjects (HD). We also assessed how circulating RBP4 could be influenced by kidney transplant or different dialytic techniques. Methods RBP4 serum levels were evaluated in HD (n = 16) ...

Journal: :The Journal of pharmacology and experimental therapeutics 2011
Araní Casillas-Ramírez Izabel Alfany-Fernández Marta Massip-Salcedo M Emília Juan Joana M Planas Anna Serafín Mercè Pallàs Antoni Rimola Juan Rodés Carmen Peralta

Numerous steatotic livers are discarded for transplantation because of their poor tolerance of ischemia-reperfusion (I/R). The injurious effects of retinol-binding protein 4 (RBP4) in various pathologies are well documented. RBP4 levels are reduced by peroxisome proliferator-activated receptor-γ (PPARγ) agonists. Strategies aimed at increasing PPARγ protect steatotic livers under warm ischemia....

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