resistance of streptococcus pneumoniae against penicillin is considered to be of great importance. while low-resistant strains could be treated by penicillin, treatment of highly resistant strains is very difficult and needs broad-spectrum antibiotics. this study was performed in imam khomeini medical center, tehran, iran, from 1999 to 2001 to evaluate pneumococcal resistance against penicillin...

children under 2 years of age suffer from some of the highest rates of invasive pneumococcal disease (ipd) in the world. (turkey) rates of ipd had a decline after statewide introduction of the 7-valent pneumococcal conjugate vaccine (pcv7) in 2008. introduction of pcv7, pcv10 and pcv13 vaccines resulted in elimination of ipd caused by vaccine serotypes, but was followed by increasing rates of i...

background and objectives:   many surface proteins are implicated in nasopharyngeal colonization and pathogenesis of streptococcus pneumoniae . some of these factors are candidate antigens for protein based vaccines. new vaccine designs focus on the surface proteins (e. g., pspa and pspc ) and also cytolysin, and pneumolysin. in this study, 3 key virulence genes, lyta , pspc , and rrga , which ...

background and objectives: streptococcus pneumoniae is the most common cause of invasive infections among both young children and elderly people. common serotypes causing invasive diseases and the emergence of carriers of streptococcus pneumoniae in iran is not yet known. past-vaccine surveillance studies of serotype prevalence patterns in iran are necessary to monitor the epidemiology of strep...

results the results of this study showed some s. pneumoniae serotypes were found in both sexes and some only in one sex invasive infections. for example, serotypes 10, 14, 18 and 22 were only in female patients with infections. conclusions the analysis of the results had suggested that serotypes 6 from lung and 19 from eye are the most abundant bacterial strains isolated from patients. the dise...

background: selective antibody deficiency with normal immunoglobulins (sadni) may be identified as part of distinct primary or secondary immunodeficiency disorders. the clinical manifestations include recurrent, often severe or prolonged, upper or lower respiratory tract infections. objectives: to evaluate sadni in patients with recurrent sinopulmonary infections and its relation to igg subclas...

Background: Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) is a leading cause of bacterial pneumonia, meningitis, and sepsis in children under 5-year of age. This study aims to estimate potentially preventable number of cases and deaths caused by Hib and pneumococcal in Iran.Materials and Methods:We used the burden of diseases model estimates of the World Health Organization (...

background: streptococcus pneumoniae and haemophilus influenzae type b (hib) is a leading cause of bacterial pneumonia, meningitis, and sepsis in children under 5-year of age. this study aims to estimate potentially preventable number of cases and deaths caused by hib and pneumococcal in iran.materials and methods:we used the burden of diseases model estimates of the world health organization (...