previous studies have demonstrated that vascular endothelial growth factor (vegf) can trigger angiogenesis as well as inflammation through binding to its membranous receptor-1 on endothelial and inflammatory cells. we aimed to correlate the circulatory number of cells expressing such receptor as well as the serum level of vegf and the soluble form of its receptor-1 (svegfr1) to the severity of ...

Specific proteolytic cleavages turn on, modify, or off the activity of vascular endothelial growth factors (VEGFs). Proteolysis is most prominent among lymph­angiogenic VEGF-C and VEGF-D, which are synthesized as precursors that need to undergo enzymatic removal their C- N-terminal propeptides before they can activate receptors. At least five different proteases mediate activating cleavage VEGF...

background: we investigated coronary angiogenesis and serum vascular endothelial growth factor (vegf) and its soluble receptor-1 (sflt-1) concentrations in two-kidney one-clip (2k1c) hypertensive rats before and after reversal of hypertension. methods: the animal groups were: (i) sham-clipped for 12 weeks; (ii) 2k1c for 12 weeks; (iii) sham-clipped for 12 weeks and unclipped for 12 weeks; and (...

background: recurrent spontaneous abortion is one of the diseases that can lead to physical, psychological, and, economical problems for both individuals and society. recently a few numbers of genetic polymorphisms in kinase insert domain-containing receptor (kdr) gene are examined that can endanger the life of the fetus in pregnant women. objective: the risk of kdr gene polymorphisms was inves...

Glioblastoma (GBM) is one of the most highly vascularized human cancers. The role exosomes in cancer angiogenesis has attracted recent interest. However, proangiogenic biomolecules transported by to facilitate GBM have not yet been identified. Here, we found a specific 120-kDa isoform vascular endothelial growth factor (VEGF) GBM-derived and confirmed it as VEGF-C. By binding VEGF receptor 2 (V...

Diabetic kidney disease (DKD) has become a global health concern, with about 40% of people living type 1 and 2 diabetes mellitus developing DKD. Upregulation vascular endothelial growth factor (VEGF) in the is significant pathology DKD associated increased glomerular permeability. To date, however, current anti-VEGF therapies have demonstrated limited success treating Recent studies shown that ...

Human bone marrow derived mesenchymal stem cells (HBMSCs) have the potential to differentiate into cells such as adipocyte, osteocyte, hepatocyte and endothelial cells. In this study, the differentiation of hBMSCs into endothelial like-cells was induced in presence of vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF-1). The differentiated endothelial cells were exam...

Objective(s): It has been demonstrated that hydrogen sulfide plays a vital role in physiological and pathological processes such as regulating inflammation, oxidative stress, and vessel relaxation. The aim of the study was to explore the effect of hydrogen sulfide on angiogenesis in the ischemic adductor muscles of type 2 diabetic db/db mice and ischemic diabetic wound...

human bone marrow derived mesenchymal stem cells (hbmscs) have the potential to differentiate into cells such as adipocyte, osteocyte, hepatocyte and endothelial cells. in this study, the differentiation of hbmscs into endothelial like-cells was induced in presence of vascular endothelial growth factor (vegf) and insulin-like growth factor (igf-1). the differentiated endothelial cells were exam...