Summary Loss of lymphocytes, particularly T cell apoptosis, is a central pathological event after severe tissue injury that associated with increased susceptibility for life-threatening infections. The precise immunological mechanisms leading to death acute are largely unknown. Here, we identified monocyte-T interaction driving bystander cells in ischemic stroke and burn injury. Specif...

Innate immune detection of nucleic acids is important for initiation of antiviral responses. Detection of intracellular DNA activates STING-dependent type I interferons (IFNs) and the ASC-dependent inflammasome. Certain members of the AIM2-like receptor (ALR) gene family contribute to each of these pathways, but most ALRs remain uncharacterized. Here, we identify five novel murine ALRs and perf...