Chronic inflammation is a key factor in symptomology and comorbidities of post-traumatic stress disorder (PTSD). Levels proinflammatory marker, C-reactive protein (CRP) are increased individuals with PTSD but it not clear if this due to trauma exposure or PTSD. Our study aimed assess the relationship between serum CRP levels, SNPs, methylation, mRNA expression homogenous exposed Australian Viet...

The current review evaluates how inflammasomes and immune checkpoints are regulated in pre-eclampsia (PE) associated with tuberculosis (TB) Human Immune Deficiency Virus (HIV). Studies indicate that such as (NRLP3, NEK7, AIM2) (CLT4, PD-1, TIM3, LAG-3) dysregulated TB- HIV-infected individuals, also pre-eclamptic pregnancies, which explains why pregnant women who either infected TB or HIV have ...

Abstract The inflammasome comprised of an innate immune receptor/sensor, pro-caspase-1, and a common adaptor molecule, ASC (apoptotic speck-containing protein with CARD) initiates defense inflammatory response by activating caspase-1 pyroptotic cell death in myeloid cells. Consistent their pro-inflammatory function, caspase-1, NLRP3 were known to exacerbate autoimmunity during experimental auto...

Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine maturation and cell death. AIM2 and NLRP3 are representative sensor proteins in two major families of inflammasomes. The adaptor protein ASC bridges the sensor proteins and caspase-1 to form ternary inflammasome complexes, achieved through pyrin domain (PYD) interactions between sensors and ASC and through caspa...

PFAPA syndrome is the most common autoinflammatory disorder in childhood with unknown etiology. The aim of our study was clinical evaluation of PFAPA patients from a single tertiary care center and to determine whether variations of AIM2, MEFV, NLRP3, and MVK genes are involved in PFAPA pathogenesis. Clinical and laboratory data of consecutive patients with PFAPA syndrome followed up at the Uni...