Human prostate cancer frequently metastasizes to bone marrow. What defines the cellular and molecular predilection for prostate cancer to metastasize to bone marrow is not well understood. CD4(+)CD25(+) regulatory T (Treg) cells contribute to self-tolerance and tumor immune pathology. We now show that functional Treg cells are increased in the bone marrow microenvironment in prostate cancer pat...

bone marrow is a primary source of various kinds of blood cells and, thus, is frequently used for evaluation of therapeutic agents. the influence of physical regular training and curcumin supplementation on the cellularity of the femur bone marrow was investigated in rats exposed to lead acetate. 48 the wistar rats were randomly assigned to one of the six groups include; 1)base, 2)sham-operate,...

Bone marrow-derived cells including osteoblastic progenitors can be concentrated rapidly from bone marrow aspirates using the surface of selected implantable matrices for selective cell attachment. Concentration of cells in this way to produce an enriched cellular composite graft improves graft efficacy. The current study was designed to test the hypothesis that the biologic milieu of a bone ma...

Bone marrow is the point of origin of several cell types, including stromal cells. Adherent bone marrow stromal cells can differentiate into chondrocytes, adipocytes and osteoblasts. Several substances which modulate the dynamics and differentiation of bone marrow stromal cells have been identified. Recently it has been discovered that those bone marrow cells which are non-adherent in tissue cu...