BACKGROUND Neuropathic pain resulting from diverse causes is a chronic condition for which effective treatment is lacking. The goal of this study was to test whether dexamethasone exerts a preemptive analgesic effect with bupivacaine when injected perineurally in the spared nerve injury model. METHODS Fifty rats were randomly divided into five groups. Group 1 (control) was ligated but receive...

BACKGROUND Surgeon satisfaction and patient analgesia during the procedure of laparoscopic surgery are important issues. The aim of this work was to study if an intrathecal (IT) Bupivacaine combined with Magnesium sulfate may or may not provide good surgeon satisfaction in addition to improvement of intraoperative and postoperative analgesia. METHODS Sixty female patients were enrolled in thi...

The effect of adrenaline on the efficacy of extradural block and plasma bupivacaine concentrations was investigated in women undergoing elective (n = 40) and emergency (n = 40) Caesarean section. Patients were randomly allocated within these two groups to receive 0.5% bupivacaine 20 ml either plain or with adrenaline 1 in 200,000, as a single fractionated extradural injection. The elective plai...

The transfer of fentanyl has been studied in the perfused in situ rabbit placenta. Does were infused with fentanyl and, subsequently, with fentanyl plus bupivacaine and pethidine. Antipyrine was infused throughout as an index of materno-fetal exchange. The fetal side of one placenta was perfused artificially with Krebs buffer containing dextran, and the effluent collected from the umbilical vei...

Plain bupivacaine 0.5% or 0.75% was injected intrathecally in four groups of 10 patients. Group A received 0.75% bupivacaine 2.7 ml at L3/4, group B 0.5% bupivacaine 4 ml at L3/4, group C 0.75% bupivacaine 2.7 ml at L2/3 and group D 0.75% bupivacaine 2 ml at L3/4. A very wide range of height of block was found in each group and because of this there were few statistically significant difference...

Background: The aim of this study is to compare the effects of Dexmedetomidine and Fentanyl as intrathecal adjuvant to Bupivacaine on the onset and duration of sensory and motor block in orthopaedic lower limb surgeries. Methods: Ninety patients of ASA status I and II posted for lower limb surgery were randomly divided into three groups. Group D was administered Hyperbaric Bupivacaine 15 mg + D...

myotoxic drug bupivacaine (Marcaine) into the rat tibialis anterior muscle. Doses of 1.5 and 1 .O% wt/vol produce significant levels of muscle regeneration, but these doses also produce large regions of ischemic muscle. Doses of 0.75 and 0.5% bupivacaine are also effective in inducing regeneration and produce little or no ischemia. Regenerating muscle is significantly more active in the incorpo...

PURPOSE Postoperative pain pumps are increasingly used to deliver a continuous infusion of local anesthetic into the surgical wound or the joint. Recently, there have been concerns that the use of such devices may be associated with chondrotoxicity and even cases of chondrolysis in the shoulder. An experimental model is presented that investigates potential chondrotoxic effects of a continuous ...

The purpose of the current study was to determine whether infiltration of bupivacaine in the incision site of midline laparotomy reduces postoperative pain and opioid consumption. Fifty-six, 30-60 year-old patients who were undergoing midline laparotomy were enrolled in the present study. The patients were randomly assigned into two groups of control (group C, n = 28) or bupivacaine (group B, n...

Objective: To compare the mean pain score of intra-peritoneal bupivacaine versus saline solution in patients undergoing laparoscopic cholecystectomy for cholelithiasis. Material and methods: Between April 2021 to October 2021, total 100 diagnosed cholelithiasis having age 18-70 years, either gender planned undergo under general anesthesia with ASA I-II were selected from Department Surgery, May...