Calcineurin B homologous proteins (CHP) are N-myristoylated, EF-hand Ca(2+)-binding proteins that bind to and regulate Na(+)/H(+) exchangers, which occurs through a variety of mechanisms whose relative significance is incompletely understood. Like mammals, Caenorhabditis elegans has three CHP paralogs, but unlike mammals, worms can survive CHP loss-of-function. However, mutants for the CHP orth...

BACKGROUND/AIMS The aim of this study was to compare the progression of aortic stiffness in chronic hemodialysis patients (CHP) with that of general population patients (GPP) over a 36-month period and to evaluate the determinants of this progression. METHODS The study group included 80 patients undergoing hemodialysis (aged 59.3 ± 11.8 years; duration of dialysis 5.47 ± 5.16 years). The cont...

PURPOSE We developed a complex of tumor antigen protein with a novel nanoparticle antigen delivery system of cholesteryl pullulan (CHP). To target HER2 antigen, we prepared truncated HER2 protein 1-146 (146HER2) complexed with CHP, the CHP-HER2 vaccine. We designed a clinical study to assess the safety of the vaccine and HER2-specific T-cell immune responses measured by the newly developed enzy...

Photoinduced intramolecular charge separation (CS) in a polar polymer glass, cyanoethylated pullulan (CN-PUL), was studied below the glass transition temperature (Tg=395 K). A series of three carbazole (Cz: donor)-cyclohexane (S: spacer)-acceptor (A: acceptor) molecules (Cz-S-A) was used as intramolecular donor-acceptor dyads. The photoinduced CS rate was evaluated by the fluorescence decay mea...

This work addresses the analysis and validation of modular CHP specifications for asynchronous circuits, using formalisms and tools coming from the field of distributed software. CHP specifications are translated into an intermediate format (IF) based on communicating extended finite state machines. They are then validated using the IF environment, which provides model checking and bi-simulatio...

In this article the place and capacity of combined heat and power [CHP] prediction unit wasdetermined dynamically with use of modified particle swarm optimization (MPSO). It was done inoptimization palace and with a capacity of CHP as a production resource with the aim to increasethe reliability capacity. Decrease the loss and provide the electrical and thermal energies ofindustrial city. The f...

While having no antitumor effect per se, caffeine substantially enhanced the antitumor effects of the phleomycins PLM-CHP and PLM-PEP, and the bleomycins BLM-CHP and Blenoxane in rats carrying Walker 256 carcinosarcoma and/or mice carrying Ehrlich ascites tumor, even at doses of phleomycin and bleomycin below the minimum effective level. Positive but less conclusive results were also obtained w...

Results: imDCs were more numerous in AgP than ChP and Control groups, being statistically significant only the S100+ cells. Conversely, mDCs were visualized in higher number in ChP than AgP and Control groups (both p<0.05). Considering the frequency of immunostained cells, the number of S100+ cells was greater than CD207+ and CD1a+ cells, followed by a lesser number of CD208+ cells, in all groups.

It has long been recognized that combined heat and power (CHP) generation can achieve higher end-use efficiencies than conventional systems. By generating electricity at the point of use and utilizing the co-produced heat, CHP generators can achieve net efficiencies in excess of 80%. This nearly doubles the efficiency of our current system, in which large centralized power plants provide electr...

Background. Adequate fluid management could be essential to minimize high arterial stiffness observed in chronically hemodialyzed patients (CHP). Aim. To determine the association between body fluid status and central and peripheral arterial stiffness levels. Methods. Arterial stiffness was assessed in 65 CHP by measuring the pulse wave velocity (PWV) in a central arterial pathway (carotid-femo...