7 The UK whole-wheat bioethanol and straw and DDGS based combined heat and power 8 (CHP) generation systems were assessed for environmental sustainability using a range of 9 impact categories or characterisations (IC): cumulative primary fossil energy (CPE), land use, 10 life cycle global warming potential over 100 years (GWP100), acidification potential (AP), 11 eutrophication potential (EP) a...

Cytophagic histiocytic panniculitis (CHP) is a rare panniculitis in childhood, associated either with nonmalignant conditions or with subcutaneous panniculitis-like T-cell lymphoma (SPTCL), and often also associated with macrophage activation syndrome (MAS). Discriminating between these 2 conditions is therapeutically important because nonmalignant CHP often improves under cyclosporine and pred...

BACKGROUND A variety of N-glycans attached to protein are known to involve in many important biological functions. Endoplasmic reticulum (ER) and Golgi localized enzymes are responsible to this template-independent glycan synthesis resulting glycoforms at each asparagine residues. The regulation mechanism such glycan synthesis remains largely unknown. METHODOLOGY/PRINCIPAL FINDINGS In order t...

A phase I+II clinical trial of vaccination with MAGE-A4 protein complexed with cholesteryl pullulan melanoma antigen gene-A4 nanogel (CHP-MAGE-A4) is currently underway in patients with MAGE-A4-expressing cancer. In the present study, the primary phase I endpoint was to test the safety of the administration of 300 µg CHP-MAGE-A4 with and without OK-432. Another aim of the study was to clarify t...

In the last decade, voluntary environmental programs have increased considerably in scope. A novel use of these programs is to di¤use new technology in industry as means to improving their environmental outcomes. This paper tests whether the US Environmental Protection Agency’s Combined Heat-and-Power Partnership has encouraged the installation of CHP applications since its start in 2001. Two h...

Neuroblastoma (NBL) and medulloblastoma (MBL) are tumors of the neuroectoderm that occur in children. NBL and MBL express Trk family tyrosine kinase receptors, which regulate growth, differentiation, and cell death. CEP-751 (KT-6587), an indolocarbazole derivative, is an inhibitor of Trk family tyrosine kinases at nanomolar concentrations. This study was designed to determine the effect of CEP-...

To elicit specific cellular immune responses against cancer, the development of efficient devices to deliver tumor antigen peptides to the MHC class I pathway constitutes a central issue. We report here a novel formula of hydrophobized polysaccharide nanoparticles, which can deliver a HER2 oncoprotein containing an epitope peptide to the MHC class I pathway. A protein consisting of the 147 amin...

This study assesses the potential environmental impacts related to energy valorization of agro-food industry waste thought Life Cycle Assessment methodology (ISO 14040). The system examined consists a real anaerobic digester coupled with combined and heat power plant (AD-CHP) operating in Sicily. analysis accounts for all occurring from delivery biomass AD-CHP up electricity generation CHP. mai...

Objective This study evaluated the influence of glycemic control on the levels and frequency of subgingival periodontal pathogens in patients with type 2 diabetes mellitus (DM) and generalized chronic periodontitis (ChP). Material and Methods Fifty-six patients with generalized ChP and type 2 DM were assigned according to the levels of glycated hemoglobin (HbA1c) into one of the following gro...