نتایج جستجو برای: k.83

تعداد نتایج: 7  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999
S J Garforth T A Ceska D Suck J R Sayers

Efficient cellular DNA replication requires the activity of a 5'-3' exonuclease. These enzymes are able to hydrolyze DNA.DNA and RNA.DNA substrates exonucleolytically, and they are structure-specific endonucleases. The 5'-3' exonucleases are conserved in organisms as diverse as bacteriophage and mammals. Crystal structures of three representative enzymes identify two divalent-metal-binding site...

Journal: :PLoS ONE 2008
Ingrid B. Müller Julia Knöckel Matthew R. Groves Rositsa Jordanova Steven E. Ealick Rolf D. Walter Carsten Wrenger

BACKGROUND Plants, fungi, bacteria and the apicomplexan parasite Plasmodium falciparum are able to synthesize vitamin B6 de novo, whereas mammals depend upon the uptake of this essential nutrient from their diet. The active form of vitamin B6 is pyridoxal 5-phosphate (PLP). For its synthesis two enzymes, Pdx1 and Pdx2, act together, forming a multimeric complex consisting of 12 Pdx1 and 12 Pdx2...

Journal: :Molecules 2016
Cecilia Ortiz Francesca Moraca Andrea Medeiros Maurizio Botta Niall Hamilton Marcelo A Comini

Glucose-6-phosphate dehydrogenase (G6PDH) plays a housekeeping role in cell metabolism by generating reducing power (NADPH) and fueling the production of nucleotide precursors (ribose-5-phosphate). Based on its indispensability for pathogenic parasites from the genus Trypanosoma, G6PDH is considered a drug target candidate. Several steroid-like scaffolds were previously reported to target the a...

ژورنال: :بلورشناسی و کانی شناسی ایران 0
سمیه یزدانیان department of physics, faculty of sciences, ferdowsi university of mashhad, mashhad, iranمشهد، دانشگاه فردوسی مشهد، دانشکده علوم پایه، گروه فیزیک، آزمایشگاه تحقیقاتی حالت جامد ناصر تجبر department of physics, faculty of sciences, ferdowsi university of mashhad, mashhad, iranمشهد، دانشگاه فردوسی مشهد، دانشکده علوم پایه، گروه فیزیک، آزمایشگاه تحقیقاتی حالت جامد محمد بهدانی department of physics, faculty of sciences, ferdowsi university of mashhad, mashhad, iranمشهد، دانشگاه فردوسی مشهد، دانشکده علوم پایه، گروه فیزیک، آزمایشگاه تحقیقاتی حالت جامد

در این پژوهش نانو بلورک­های ابررسانای δ-7o3cu2yba )1 > d >0)، به روش مکانوشیمیایی ساخته شدند. این ترکیب با استفاده از پودرهای 3baco، 3o2y، cuo پس از 5 ساعت آسیاکاری در دستگاه آسیای spex 8000  با نسبت وزنی ده به یک گلوله به پودر و گلوله های فولادی به قطر  mm11 و سپس گرمادهی به مدت 4 ساعت در دمایoc 850 شکل گرفت. به منظور تشکیل کاملتر فاز ابررسانا، مرحله­ی تفجوشی همراه با اکسی‍ژن­دهی روی نمونه­ها ...

1997
A Kriegl

Smooth, real analytic and holomorphic mappings deened on non-open subsets of innnite dimensional vector spaces are treated. 0. Introduction In this paper we will generalize the concept of diierentiable maps f : E X ! F deened on open subsets to such on more general subsets of innnite dimensional vector spaces. We will refer to the theories for open domains as they have been developed in K82], K...

Journal: :Biochimica et biophysica acta 2006
Chunlong Ma Sreevidya Remani Rusudan Kotaria June A Mayor D Eric Walters Ronald S Kaplan

Previous examination of the accessibility of a panel of single-Cys mutants in transmembrane domain III (TMDIII) of the yeast mitochondrial citrate transport protein to the hydrophilic, cysteine-specific methanethiosulfonate reagent MTSES enabled identification of the water-accessible surface of this TMD. Further studies on the effect of citrate on MTS reagent accessibility, indicated eight site...

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