background there have been many concerns about alteration in hemodynamic parameters within and shortly after endotracheal intubation (eti) in patients scheduled for elective coronary artery bypass grafting (cabg). objectives we compared the attenuation effect of magnesium sulfate and lidocaine on hemodynamic responses after eti, in patients undergoing cabg. patients and methods in this randomiz...

In this paper, the photocatalytic degradation of Lidocaine HCl, an anesthetic was investigated inaqueous solution using CuO/ZnO as a photocatalyst. The degradation was studied under differentconditions including the amount of the photocatalyst, irradiation time, initial concentration of drug,pH of the system, initial concentration, addition of oxidant on the reaction rate and anion presence.The...

BACKGROUND Adding epinephrine to lidocaine solutions for peripheral nerve block potentiates and prolongs the action, but by incompletely understood mechanisms. In an effort to discriminate the pharmacokinetic from the pharmacodynamic effects of epinephrine, the authors measured the lidocaine content of peripheral nerve over the course of block produced by 0.5% lidocaine, with and without epinep...

STUDY OBJECTIVE To compare pain on infiltration, need for additional anesthesia, and pain on suturing in patients given plain, warm, and buffered lidocaine preparations before the suturing of traumatic wounds in the emergency department. DESIGN Randomized, prospective, single-blinded convenience sample. SETTING University hospital ED. PARTICIPANTS Patients with traumatic lacerations. Pati...

BACKGROUND Lidocaine has been used widely to prevent propofol injection pain. Various methods of administration exist, such as lidocaine premixed with propofol or lidocaine pretreatment using a tourniquet, but it is unclear which method of lidocaine administration is more effective for the prevention of injection pain of propofol LCT/MCT. The purpose of this study was to compare pretreatment of...

Phentolamine mesylate accelerates recovery from oral soft tissue anesthesia in patients who have received local anesthetic injections containing a vasoconstrictor. The proposed mechanism is that phentolamine, an alpha-adrenergic antagonist, blocks the vasoconstriction associated with the epinephrine used in dental anesthetic formulations, thus enhancing the systemic absorption of the local anes...

Background: Various drugs are used as adjuvants to improve the quality of supraclavicular block. Objective: This study aimed to investigate the effect of adding dexmedetomidine to lidocaine on the characteristics of supraclavicular block in upper limb surgeries. Methods: This double-blind controlled clinical trial was conducted on patients undergoing upper extremity fracture surgery under a ...

The inappropriate activation, positioning, and recruitment of leukocytes are implicated in the pathogenesis of multiple organ failure in sepsis. Although the local anesthetic lidocaine modulates inflammatory processes, the effects of lidocaine in sepsis are still unknown. This double-blinded, prospective, randomized clinical trial was conducted to investigate the effect of lidocaine on leukocyt...