Case Presentation: A 66-year-old retired man presented to his physician with complaints of shortness of breath and weight gain over 1 week’s time during a recent cruise. He was not short of breath in the supine position, although his neck veins were distended. The blood pressure was 196/ 104 mm Hg; his heart rate was 92 bpm; and his cardiac rhythm was normal. He had a large habitus and was 76 i...

U M LTIORGAN harvesting for individual organ transplantation is well defined according to the principles of Starzl. However, some pancreatic transplant surgeons believe the pancreas should not suffer hyperperfusion as occurs in multiorgan harvesting. This is in conflict with the need of all donor organs for transplantation and specially when multivisceral transplantation is planned. We believe ...

AIMS To evaluate patterns of multiorgan dysfunction and neurologic outcome in children with respiratory and cardiac arrest after drowning. METHODS Single center retrospective chart review of children aged 0-21 years admitted between January 2001 and January 2012 to the pediatric intensive care unit at Children's Hospital of Pittsburgh with a diagnosis of drowning/submersion/immersion. Organ d...

In vivo studies of the metastatic process are severely hampered by the fact that most human tumor cell lines derived from highly metastatic tumors fail to consistently metastasize in immunodeficient mice like nude mice. We describe a model system based on a highly immunodeficient double knockout mouse, Rag2-/-;Il2rg-/-, which lacks T, B and NK cell activity. In this model human metastatic HER-2...

Intravascular large B-cell lymphoma is an extremely rare extranodal lymphoma that proliferates in the lumen of the blood vessels while sparing the organ parenchyma. It usually presents with CNS and skin involvement. A 65-year-old Caucasian female presented with fevers and chills of 3-4 months' duration. Bone marrow biopsy done 3 months prior showed no significant myelodysplasia or lymphoid aggr...