Despite the near concurrent publication by influential scientific organizations, there are important differences in interpretation of the evidence base and the conclusions derived from the recent Osteoarthritis Research Society International (OARSI) guidelines for the management of knee osteoarthritis, the American College of Rheumatology (ACR) guidelines (concerning also hip and hand osteoarth...

INTRODUCTION Pain is the primary outcome measurement in osteoarthritis, and its assessment is mostly based on its intensity. The management of this difficult chronic condition could be improved by using pain descriptors to improve analyses of painful sensations. This should help to define subgroups of patients based on pain phenotype, for more adapted treatment. This study draws upon patients' ...

BACKGROUND Leg-length inequality is common in the general population and may accelerate development of knee osteoarthritis. OBJECTIVE To determine whether leg-length inequality is associated with prevalent, incident, and progressive knee osteoarthritis. DESIGN Prospective observational cohort study. SETTING Population samples from Birmingham, Alabama, and Iowa City, Iowa. PATIENTS 3026 ...

Purpose: high tibial osteotomy (HTO) is a recommended treatment for medial compartment knee osteoarthritis. Newer cartilage regenerative procedures may add benefits to the result of HTO. In this prospective study we investigate safety and also results of HTO associated with bone marrow derived cells (BMDC) transplantation in relatively young and middle aged active individuals with early osteoar...

Background: This is a case series of 76 knees of 62 patients who underwent upper tibial valgus osteotomy for treatment of medial compartment osteoarthritis during a 20-year period and who were followed for a mean of 7.6 years. Methods: The patients were evaluated by validated outcome assessment systems of general health status short form (SF-36), the Western Ontario McMaster osteoarthritis inde...

OBJECTIVE To investigate the relationship between body mass index (BMI) and the incidence and progression of radiological knee as well as of radiological hip osteoarthritis. DESIGN Cohort study. SETTING Population based. PARTICIPANTS 3585 people aged > or =55 years were selected from the Rotterdam Study, on the basis of the availability of radiographs of baseline and follow-up. MAIN OUT...

OBJECTIVES To investigate the risk of incident rheumatoid arthritis in patients with symptomatic osteoarthritis or osteoarthritis-related surgery using a nationwide health claims database. DESIGN A nationwide, population-based, case-control study. SETTING Taiwan's National Health Insurance Research Database. PARTICIPANTS A total of 1147 patients (aged 20-100 years) with rheumatoid arthrit...