BACKGROUND The matrilin, especially matrilin-3 (MATN3), are reported to play important roles in the pathophysiology of osteoarthritis (OA). To explore the relationship between MATN3 SNP6 (rs8176070) and primary OA, we conducted a community-based case-control study. METHODS A total of 732 community residents aged 40-84 years participated in the community-based study in Northeast China. After t...

OBJECTIVE Osteoarthritis is a global clinical challenge for which no effective disease-modifying agents currently exist. This study identified protease-activated receptor 2 (PAR-2) as a novel pathogenic mechanism and potential therapeutic target in osteoarthritis. METHODS Experimental osteoarthritis was induced in wild-type and PAR-2-deficient mice by sectioning the medial meniscotibial ligam...

OBJECTIVES To investigate differing patterns and associations of osteoarthritis of the knee in patients referred to hospital. METHODS Two hundred and fifty two consecutive patients (161 women, 91 men; mean age 70 years, range 34-91 years) referred to hospital with osteoarthritis of the knee underwent clinical, radiographic, and synovial fluid screening. RESULTS Radiographic changes of osteo...

Hip and knee osteoarthritis are common, chronic, and disabling. Therapeutic exercise is a component of all major rheumatologic society guidelines, yet the frequency, dose, duration, and therapeutic threshold for exercise are not clearly delineated. This review summarizes current studies of exercise for hip and knee osteoarthritis, discusses issues that influence the design, interpretation, and ...

Abstract Introduction Osteoarthritis is more common than any other joint disease, and patients often ask what the cause is, enquiring about environmental causes, such as previous occupation. The available literature suggests that factors such as increasing age, gender (female), obesity and genetics may all lead to the development of osteoarthritis of the hand or wrist. It is a multifactorial, h...

OBJECTIVES It has been suggested that the lysosomal recycling process called macro-autophagy plays a role in osteoarthritis development. We thus decided to genetically ablate the autophagy-indispensable Atg5 gene specifically in chondrocytes and analyse the development of osteoarthritis upon aging and in a post-traumatic model. METHODS Mice lacking the Atg5 gene in their chondrocytes (Atg5cKO...

contribution to radiographic hip osteoarthritis in women: results of a classic twin study. Arthritis Rheum 2000;43:2410–16. 22 Antoniades L, MacGregor AJ, Matson M, Spector TD. A cotwin control study of the relationship between hip osteoarthritis and bone mineral density. Arthritis Rheumatism 2000;43:1450–5. 23 Bellamy N, Klestov A, Muirden K, Kuhnert P, Do KA, O’Gorman L, et al. Perceptual var...

INTRODUCTION Osteoarthritis is influenced by genetic and environment factors, including mechanical stress; however, the relationship between running and the development of osteoarthritis remains a matter of controversy. We investigated whether osteoarthritic change could be obtained in a rat strenuous running model, whether serum keratan sulfate in rats could be detected by HPLC and was associa...

BACKGROUND Although age is the strongest predictor of osteoarthritis, the exact mechanism underlying this disorder remains elusive. OBJECTIVE To examine the association between leucocyte telomere length (LTL), a bio-indicator of ageing, and radiographic hand osteoarthritis. METHODS An unselected, predominantly female sample from the TwinsUK Adult Twin Registry (Twin Research and Genetic Epi...

Abstract Pain is one of the most prominent symptoms of osteoarthritis. However, there is often discordance between the pain experienced by individuals with osteoarthritis and the degree of articular pathology. This suggests that individual differences, including genetic variability in the central processing of nociceptive stimuli, may impact the presentation of osteoarthritis. Here, we show tha...