Clinical Presentation: A 5-year-old girl of Ashkenazi origin was referred to our pediatric endocrine clinic because of short stature. The child generally had good health aside from several episodes of otitis media. She was born at term after a normal pregnancy and delivery; birth weight was 2400 g, and birth length was not recorded. There was no history of intrauterine infection, toxemia, or ex...

Pre-eclamptic toxaemia (PET) may be associated with both endothelial dysfunction (ED) and sleep-disordered breathing (SDB). It was hypothesised that females with PET would demonstrate both SDB and ED, and that a correlation between these two would suggest a potential causative association. A total of 17 females with PET and 25 matched females with uncomplicated pregnancy were studied. They unde...

This study was undertaken as the result of a discussion of the relationship of toxemia of pregnancy to acute nephritis. It was thought that if hemolytic streptococcal infection played any such part in toxemia as it has been shown to play in many instances of acute nephritis, this might perhaps be detected by use of the antifibrinolysin test. It was first shown by Tillett and Garner4 in 1933 tha...

In the 1950s and 1960s, researchers Leon Chesley, John Annitto, and Robert Cosgrove investigated the possible familial factor for the conditions of preeclampsia and eclampsia in pregnant women. Preeclampsia and eclampsia, which are related to high blood pressure, have unknown causes and affect at least five percent of all pregnancies. The researchers, who worked at Margaret Hague Maternity Hosp...

The beneficial effect of blood letting in the toxemias of late pregnancy is well recognized, but little or no accurate information is available concerning the method of its action. During the course of investigations on the water concentration and the acid-base balance in a series of patients with various clinical types of toxemia (1), certain observations were made at different times in the sa...

Wlhen Chesley and Williams demonstrated low uric acid excretion in toxemiiic patients,1 they noted that the reduction in renal urate clearance was relatively greater than the reduction in glomerular filtration rate (1). This relationship has been confirmed (2) and is striking when c-ompared with observations on urate excretion in normal slibjects and patients with renal disease. It is generally...

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In previous papers (9, 14) we have discussed the changes that occur in the acid-base equilibrium of serum of normal women during pregnancy. In brief, these changes are reduction of the serum carbon dioxide content and serum proteins, accompanied by a comparable reduction of total base. These findings have been confirmed by Stander, Eastman, Harrison, and Cadden (21). The reduction of serum prot...

BACKGROUND The aim of this study was to determine the safety of sublingual immunotherapy in pregnancy, which has not yet been reported. METHODS One hundred and fifty-five patients received sublingual immunotherapy with either house dust mite (D. farinae) or a mixture of up to five allergens during 185 pregnancies. Twenty-four patients received sublingual immunotherapy for the first time durin...