Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated l-fucose. Heterofucan SF-1.5v was extracted from the brown seaweed Sargassum filipendula by proteolytic digestion followed by sequential acetone precipitation. This fucan showed antiproliferative activity on Hela cells and induced apoptosis. However, SF-1.5v was not able to activate caspases. Moreover, SF-1...

Silk fibroin (SF) is a natural, degradable, fibrous protein that is biocompatible, is easily processed, and possesses unique mechanical properties. Another natural material, wool keratose (WK), is a soluble derivative of wool keratin, containing amino acid sequences that induce cell adhesion. Here, we blended SF and WK to improve the poor electrospinability of WK and increase the adhesiveness o...

Biocomposites of low-density polyethylene (LDPE) and polypropylene (PP) with 5–40wt% soy flour (SF) are produced by two-step single-screw extrusion (SSE) followed by solid-state shear pulverization (SSSP). The SSE-SSSP approach overcomes limitations with melt mixing, e.g poor SF dispersion and degradation, and limitations with single-step SSSP. Microscopy shows that SF is well dispersed in SSE-...

Steroidogenic factor 1 (SF-1) is a transcription factor expressed in the ventral medial nucleus of the hypothalamus that regulates energy homeostasis. However, the molecular mechanisms of SF-1 in the control of energy balance are largely unknown. Here, we show that nutritional conditions, such as the presence or absence of serum, affect SF-1 action. Serum starvation significantly decreased hypo...

The stability of 10 active pharmaceutical ingredients was studied in SyrSpend SF PH4 or SyrSpend SF Alka at room and/or refrigerated temperature (2°C to 8°C). An oral suspension of each active pharmaceutical ingredient was compounded in low actinic plastic bottles at a specific concentration in SyrSpend SF PH4 or SyrSpend SF Alka. Samples were assessed for stability immediately after preparatio...

To investigate the mechanisms underlying development of upright face preferences in infants, the current study measured inversion effects for faces that were spatial frequency (SF) filtered, into low SF and high SF, with the notion that different SFs are analyzed by different visual mechanisms. For comparison to faces, we used object stimuli that consisted of pictures of strollers. In 4 month o...

OBJECTIVE To quantify peptidylarginine deiminase 2 (PAD2) in SF of RA patients and OA patients, and to determine the association between PAD2 levels, disease activity and inflammatory markers in RA. METHODS Blood and SF samples were obtained from 39 RA patients and 40 patients with OA. PAD2 content and PAD activity were measured by means of in-house assays. TNF-α, IL-1β, IL-6, IL-8, IL-10 and...

Output from steroidogenic factor-1 (SF-1) neurons in the ventromedial nucleus of the hypothalamus (VMH) is anorexigenic. SF-1 neurons express brain-derived neurotrophic factor (BDNF) that contributes to the regulation of food intake and body weight. Here I show that regulation of GABAergic inputs onto SF-1 neurons by endogenous BDNF determines the anorexigenic outcome from the VMH. Single-cell ...

During gonad and adrenal development, the POD-1/capsulin/TCF21transcription factor negatively regulates SF-1/NR5A1expression, with higher SF-1 levels being associated with increased adrenal cell proliferation and tumorigenesis. In adrenocortical tumor cells, POD-1 binds to the SF-1 E-box promoter region, decreasing SF-1 expression. However, the modulation of SF-1 expression by POD-1 has not pre...

Lipoproteins of the Sf 12-100 class, representing only about 10 to 15 per cant of the serum cholesterol, are strongly associated with atherosclerosis. The major independent contributions to this association are from the Sf 12-20 lipoproteins and the Sf 35-100 lipoproteins. The Sf 20-35 lipoproteins are primarily associated by virtue of their intercorrelation with the other classes. Obesity is m...