α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading
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منابع مشابه
α‐Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading Frida Loria1 · Jessica Y. Vargas1 · Luc Bousset2 · Sylvie Syan1 · Audrey Salles3 · Ronald Melki2 · Chiara Zurzolo1
The misfolding and aggregation of specific proteins are a common neuropathological hallmark of many neurodegenerative disorders including Alzheimer’s, Parkinson’s, Huntington’s, and prion diseases [39]. Parkinson’s disease (PD), a neurodegenerative disorder related to aging, is characterized by intracellular deposits of aggregated α-synuclein (α-syn) known as Lewy bodies and Lewy neurites [12]....
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Many lines of evidence suggest that the Parkinson's disease (PD)-related protein α-synuclein (α-SYN) can propagate from cell to cell in a prion-like manner. However, the cellular mechanisms behind the spreading remain elusive. Here, we show that human astrocytes derived from embryonic stem cells actively transfer aggregated α-SYN to nearby astrocytes via direct contact and tunneling nanotubes (...
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ژورنال
عنوان ژورنال: Acta Neuropathologica
سال: 2017
ISSN: 0001-6322,1432-0533
DOI: 10.1007/s00401-017-1746-2