γ-Tocotrienol does not substantially protect DS neurons from hydrogen peroxide-induced oxidative injury

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γ-Tocotrienol does not substantially protect DS neurons from hydrogen peroxide-induced oxidative injury

BACKGROUND Down syndrome (DS) neurons are more susceptible to oxidative stress and previous studies have shown that vitamin E was able to reduce oxidative stress and improve DS neurons' viability. Therefore, this study was done to investigate the protective role of γ-tocotrienol (γT3) in DS neurons from hydrogen peroxide (H2O2) -induced oxidative stress. The pro-apoptosis tendency of γT3 was co...

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Progesterone and Cilostazol Protect mice pancreatic islets from oxidative stress induced by hydrogen peroxide

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Progesterone and Cilostazol Protect mice pancreatic islets from oxidative stress induced by hydrogen peroxide

Abstract Reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. It has been shown that progesterone and cilostazol possess antioxidant properties. The present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...

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Astrocytes protect neurons from hydrogen peroxide toxicity.

Recent reports indicate that neurons are particularly sensitive to hydrogen peroxide (H2O2). The present study was undertaken to investigate the putative role of astrocytes in the modulation of the neurotoxic effect of H2O2. The exposure to H2O2 of cultured striatal neurons from mouse embryos induced a concentration-dependent (10-1000 microM) cell death as estimated 24 hr later. Two methods wer...

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progesterone and cilostazol protect mice pancreatic islets from oxidative stress induced by hydrogen peroxide

abstract reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. it has been shown that progesterone and cilostazol possess antioxidant properties. the present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...

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ژورنال

عنوان ژورنال: Nutrition & Metabolism

سال: 2012

ISSN: 1743-7075

DOI: 10.1186/1743-7075-9-1