(+)-WAY 100135, a partial agonist, at native and recombinant 5-HT1B/1D receptors

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(+)-WAY 100135, a partial agonist, at native and recombinant 5-HT1B/1D receptors.

1. We have studied the effects of the purportedly selective 5-HT1A receptor antagonist (+)-WAY 100135 on electrically stimulated 5-hydroxytryptamine (5-HT) efflux in the ventrolateral geniculate nucleus (vLGN), and its affinity at human 5-HT1B and 5-HT1D receptors stably expressed in Chinese hamster ovary (CHO) cells. 2. On short 'pseudo single pulse' stimulations (20 pulses at 100 Hz, 190 ms t...

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BACKGROUND AND PURPOSE 5-HT3 receptors are composed of 5-HT3A subunits (homomeric receptors), or combinations of 5-HT3A and other 5-HT3 receptor subunits (heteromeric receptors, the best studied of which are 5-HT3AB receptors). Here we explore the effects of partial agonists at 5-HT3A and 5-HT3AB receptors, and the importance of a channel-lining residue in determining the efficacy of activation...

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ژورنال

عنوان ژورنال: British Journal of Pharmacology

سال: 1997

ISSN: 0007-1188

DOI: 10.1038/sj.bjp.0701197