054 Combination of thymus and activation-regulated chemokine and soluble OX40 as a diagnostic biomarker for DIHS/DRESS

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe drug-induced adverse fever, cutaneous eruptions, hematological abnormalities, organ dysfunction, reactivation of human herpesvirus 6 (HHV-6). Although rapid diagnosis necessary for the management DIHS/DRESS, it difficult to distinguish early phase DIHS/DRESS from other drug eruptions. We have previously reported that thymus activation-regulated chemokine (TARC), which plays an important role in Th2-mediated immune-inflammatory processes such as atopic dermatitis, serum soluble OX40 (CD134), has allergic inflammation functions cellular receptor HHV-6 entry, can be useful diagnostic marker DIHS/DRESS. The sensitivity specificity sOX40 (cut-off value 213 pg/ml) were 67% 80%, respectively. Those TARC 4000 72% 77%, In this study, order reveal relationship between levels acute well serological test using both we analyzed sera patients presenting our department. found two markers significantly correlated, combination increased 85% but decreased 73%. combined determination may increase detection rate