0727 Age-related association of visceral adiposity with cardiometabolic disorders in mild-to-moderate sleep apnea

Abstract Introduction Visceral adiposity is a key predictor of both metabolic syndrome and obstructive sleep apnea (OSA). Both OSA are associated with cardiometabolic disorders, however, the association these disorders weakens in older adults. We compared relative strength between visceral vs. hypertension diabetes whether this stronger middle-aged Methods A clinical sample 148 adults (53.79±12.45y, 36,5% female) mild-to-moderate (5≤AHI<30) underwent 8-hour polysomnography, history physical examination, including measures blood pressure fasting glucose. Hypertension was defined as ≥140/90mmHg or use anti-hypertensive medication. Diabetes glucose ≥100mg/dL receiving treatment for diabetes, except insulin. Adiposity Index (VAI) calculated within each sex using Amato et al (2010) standardized formulas based on waist, BMI, triglycerides HDL cholesterol. Logistic regression models examined VAI AHI while simultaneously adjusting stratifying by age. also generated under receiver-operating characteristics (ROC) curves (AUC) having outcomes gender, age, independent variables. Results greater odds (OR=1.57, 95%CI=1.20-2.06, P=0.001) (OR=1.27, 95%CI=1.02-1.57, p=0.031) to (OR=1.05, 95%CI=0.98-1.13, p=0.185; OR=1.07, 95% CI=1.00-1.14, p=0.690, respectively) aged <60y. There no ≥60y. Adding standard factors (age, sex, BMI) yielded moderately-good risk (AUC=0.73) (AUC=0.70) <60y, suboptimal (AUC=0.61 0.68, Conclusion These data indicate that adiposity, but not AHI, patients OSA, an obesity should be priority preventive/therapeutic interventions young OSA. findings further support distinctly different phenotype. Support (If Any)