092 Merkel cell polyomavirus small T antigen co-expressed with Atoh1 drives development of intraepidermal MCC
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Merkel Cell Polyomavirus Small T Antigen Drives Cell Motility via Rho-GTPase-Induced Filopodium Formation
Cell motility and migration is a complex, multistep, and multicomponent process intrinsic to progression and metastasis. Motility is dependent on the activities of integrin receptors and Rho family GTPases, resulting in the remodeling of the actin cytoskeleton and formation of various motile actin-based protrusions. Merkel cell carcinoma (MCC) is an aggressive skin cancer with a high likelihood...
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These findings contradict existing evidence showing MCV sT protein expression in MCVMCC cancer tissues (Shuda et al., 2011) and cell lines (see Figure. 2, Houben et al., 2010) (Guastafierro et al., 2013). To investigate this discrepancy, we tried replicating Angermeyer et al's results using the same antibodies to detect MCV sT (CM8E6 (Kwunet al., 2009), CM5E1 (Shuda et al., 2011) and 2T2 ((Wang...
متن کاملLarge T and small T antigens of Merkel cell polyomavirus.
Merkel cell polyomavirus (MCV) is the etiological agent of Merkel cell carcinoma (MCC), a rare and highly lethal human skin cancer. A natural component of skin flora, MCV becomes tumorigenic only after integration into the host DNA together with specific mutations to the viral genome. Research on MCV large T (LT) and small T (sT) antigens, the only viral products expressed in MCC, shows that th...
متن کاملPhosphorylation of Large T Antigen Regulates Merkel Cell Polyomavirus Replication
Merkel Cell Polyomavirus (MCPyV) was recently discovered as a novel human polyomavirus that is associated with ~80% of Merkel Cell Carcinomas. The Large Tumor antigen (LT) is an early viral protein which has a variety of functions, including manipulation of the cell cycle and initiating viral DNA replication. Phosphorylation plays a critical regulatory role for polyomavirus LT proteins, but no ...
متن کاملMerkel Cell Polyomavirus Small T Antigen Mediates Microtubule Destabilization To Promote Cell Motility and Migration
UNLABELLED Merkel cell carcinoma (MCC) is an aggressive skin cancer of neuroendocrine origin with a high propensity for recurrence and metastasis. Merkel cell polyomavirus (MCPyV) causes the majority of MCC cases due to the expression of the MCPyV small and large tumor antigens (ST and LT, respectively). Although a number of molecular mechanisms have been attributed to MCPyV tumor antigen-media...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2016
ISSN: 0022-202X
DOI: 10.1016/j.jid.2016.02.118