1. Complement

Complement receptor 1 in autoimmune disorders

Complement receptor 1 (CR1) has gained much attention in recent years. The reason is manifold. Growing understanding on this protein has facilitated insight into the pathophysiology of autoimmune disorders. CR1, a polymorphic protein, is important as a complement regulatory protein, as well as a vehicle for immune complex clearance. Functional and clinical significance of CR1 polymorphism is a ...

- 1 - Complement in Renal Transplant Rejection

The complement system plays multiple pathogenetic roles in rejection of renal allografts and one of the components, C4d, is an important diagnostic marker of antibody mediated rejection (1, 2). Complement proteins (e.g., C3) arose as an ancient, innate defense system in invertebrates that preceded the adaptive immune system in phylogeny. It is not surprising that during evolution these compleme...

Complement C 1 q subcomponent subunit A

Mouse podocyte complement factor H: the functional analog to human complement receptor 1.

Complement factor H (Cfh) is a key plasma protein in humans and animals that serves to limit alternative pathway complement activation in plasma, as well as in local sites such as capillaries of the glomerulus and eye. It was shown that rodent Cfh on platelets is the functional analogue to human erythrocyte complement receptor 1 with a role that is distinct from plasma Cfh and that Cfh is also ...

A Familial C3GN Secondary to Defective C3 Regulation by Complement Receptor 1 and Complement Factor H.

C3 glomerulopathy is a recently described form of CKD. C3GN is a subtype of C3 glomerulopathy characterized by predominant C3 deposits in the glomeruli and is commonly the result of acquired or genetic abnormalities in the alternative pathway (AP) of the complement system. We identified and characterized the first mutation of the C3 gene (p. I734T) in two related individuals diagnosed with C3GN...