137 Standing in the gap of Neonatal Microbe-Host Barrier Function

Abstract The provision of mammary secretions in the form colostrum and mature milk for newborns is an essential survival function that has evolved over millennia mammalian species. Colostrum serves a vital neonates by providing nutrients energy growth as they transition from placental nutrition to oral ingestion more complex macromolecules, including lactose, proteins, triglycerides. also provides critical immune protection colonizing commensal pathogenic microbes supports neonatal immunity until maturation system. This concept homologous passive conferred well known farm animal species been largely attributed immunoglobulins transferred mother offspring. Heterologous approach whereby bovine obtained normal or hyperimmunized cows used therapeutically prevent specific GI diseases swine human infants. importance newborn animals holds true prevention intestinal diseases, such necrotizing enterocolitis (NEC), hospitalized premature In preterm infants, mother’s own may not always be available infants are instead fed donor milk, which effective against NEC. Whether benefits NEC due established. These scenarios different mothers within protect gut point common elements host protection. New experimental approaches tools being applied understanding molecular mechanism how components maternal impact microbial colonization interaction with