14-MHz Ultrasonography as an Outcome Measure in Morphea (Localized Scleroderma)

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Ultrasonography is a sensitive tool for monitoring localized scleroderma.

OBJECTIVE To examine the usefulness of ultrasonography (USG) for monitoring paediatric localized scleroderma (LS). METHODS A retrospective chart review of six paediatric patients who had USG of their LS. RESULTS USG detected several abnormalities in active lesions including increased blood flow, increased echogenicity and loss of subcutaneous fat. USG findings corresponded with clinical ass...

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Localized Scleroderma

Morphea (localized scleroderma) is an autoimmune disease characterized by sclerosis of the skin and, in some cases, subcutaneous tissue. It occurs in children and adults. It is distinct from systemic sclerosis, but may nevertheless be associated with significant functional and cosmetic impairment. Morphea has several distinct subtypes, including circumscribed, linear, and generalized, all of wh...

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Cognition as an outcome measure in schizophrenia.

BACKGROUND Cognitive deficits are a core feature of schizophrenia. These deficits are not caused by medication or symptoms, and have a dramatic negative effect on real-world functioning. AIMS To critically examine a selection of the most common batteries used to assess cognition in schizophrenia. METHOD Literature review of cognitive assessment batteries for use in schizophrenia. RESULTS ...

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Localized scleroderma is an autoimmune disorder.

OBJECTIVES There have been many studies suggesting that localized scleroderma has a strong autoimmune background, although the lesions are usually limited to the skin and subcutaneous tissue. Here we summarize previous data on the autoimmunity of localized scleroderma, mostly published in the last two decades, because there has not been a review paper summarizing autoimmunity in this disorder. ...

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Reliability of using an ultrasound scoring measure for juvenile localized scleroderma (jLS)

Purpose Although ultrasound shows great potential for aiding assessment of LS disease activity, its use has been limited because both image acquisition and interpretation are operator dependent. To facilitate evaluating and to standardize interpretation of jLS ultrasound scans, we generated a scoring measure for evaluating echogenicity and vascularity differences (U-DA, Ped Rheum 2010;8:14). Ob...

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ژورنال

عنوان ژورنال: Archives of Dermatology

سال: 2011

ISSN: 0003-987X

DOI: 10.1001/archdermatol.2011.243