2-Microglobulin-Deficient NOD Mice Do Not Develop Insulitis or Diabetes
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Rapid Publications p2-Microglobulin-Deficient NOD Mice Do Not Develop Insulitis or Diabetes
The role of CD8 T-cells in the development of diabetes in the nonobese diabetic (NOD) mouse remains controversial. Although it is widely agreed that class II-restricted CD4 T-cells are essential for the development of diabetes in the NOD model, some studies have suggested that CD8 T-cells are not required for p-cell destruction. To assess the contribution of CD8 T-cells to diabetes, we have dev...
متن کاملInsulitis in NOD Mice
The active form of vitamin D, 1,25(OH)2D3, can prevent various forms of experimentally induced autoimmune disorders. The aim of this study was to confirm these findings in NOD mice that spontaneously develop an autoimmune type of diabetes mellitus. Therefore, the effect of a long-term 1,25(OH)2D3 treatment on the incidence of insulitis, the histological lesion preceding diabetes, was studied. F...
متن کاملMajor histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant.
Specific allelic combinations within the class II region of the major histocompatibility complex (MHC) represent a major genetic component for susceptibility to autoimmune insulin-dependent diabetes mellitus (IDDM) in humans. We produced and used a stock of NOD/Lt mice congenic for a functionally inactivated beta 2-microglobulin (B2mnull) locus to assess whether there was an absolute requiremen...
متن کاملI-E+ nonobese diabetic mice develop insulitis and diabetes
The development of type I diabetes in the nonobese diabetic (NOD) mouse is under the control of multiple genes, one or more of which is linked to the major histocompatibility complex (MHC). The MHC class II region has been implicated in disease development, with expression of an I-E transgene in NOD mice shown to provide protection from insulitis and diabetes. To examine the effect of expressin...
متن کاملLongitudinal Frequencies of Blood Leukocyte Subpopulations Differ between NOD and NOR Mice but Do Not Predict Diabetes in NOD Mice.
Immune phenotyping provides insight into disease pathogenesis and prognostic markers. Trajectories from age of 4 to 36 weeks were modeled for insulin autoantibodies and for leukocyte subpopulations in peripheral blood from female NOD (n = 58) and NOR (n = 22) mice. NOD mice had higher trajectories of insulin autoantibodies, CD4(+) and CD8(+) T lymphocytes, B lymphocytes, IgD(+)IgM(-) B lymphocy...
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ژورنال
عنوان ژورنال: Diabetes
سال: 1994
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diab.43.3.500