206 An immune-competent tumor organoid platform to test novel immune checkpoint combinations targeting the receptor CD47 in triple negative breast cancer
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منابع مشابه
Immune Checkpoint Inhibitors in Triple Negative Breast Cancer
The role of immune system in treating cancer is being increasingly seen as important [1]. Cancer cells have oncogenic mutations and express neo-antigens that make them distinct from normal cells thus prone to immune recognition. However, cells of innate and adaptive immune system which recognize and destroy these cells are held in check by various molecular pathways called “immune checkpoints” ...
متن کاملTumor-Infiltrating Lymphocytes in Triple Negative Breast Cancer: The Future of Immune Targeting
Triple negative breast cancer (TNBC) is a highly heterogeneous tumor. There is increasing evidence of the role of tumor lymphocytic immune infiltrates in this subtype of breast cancer. Robust levels of tumor infiltrating lymphocytes (TILs) have been associated with improved disease-free and overall survival rates in TNBC patients with and without any treatment. Recent efforts have been made to ...
متن کاملIs CD47 an innate immune checkpoint for tumor evasion?
Cluster of differentiation 47 (CD47) (also known as integrin-associated protein) is a ubiquitously expressed glycoprotein of the immunoglobulin superfamily that plays a critical role in self-recognition. Various solid and hematologic cancers exploit CD47 expression in order to evade immunological eradication, and its overexpression is clinically correlated with poor prognoses. One essential mec...
متن کاملImmunotherapy for Triple-Negative Breast Cancer: A Focus on Immune Checkpoint Inhibitors
Introduction Triple-negative breast cancer (TNBC) is clinically defined as breast tumors lacking expression of estrogen receptor (ER) and progesterone receptor, with normal human epidermal growth factor receptor type 2 (HER2) gene copy number and expression. It accounts for approximately 15% to 20% of all breast cancers and is more prevalent in younger women and in African-American women. TNBC ...
متن کاملImmune targeting in breast cancer.
The immune system is active in breast cancer, playing a dual role in tumor progression and in immune surveillance. Infiltrating immune cells are both prognostic and predictive of response to standard breast cancer therapies. Breast cancer vaccines can activate and expand tumor-specific T cells, but have enjoyed minimal clinical success to date. Immune checkpoint blockade is a new approach to ca...
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ژورنال
عنوان ژورنال: Journal for ImmunoTherapy of Cancer
سال: 2020
ISSN: 2051-1426
DOI: 10.1136/jitc-2020-sitc2020.0206