283: Maternal secretor status and the milk microbiota composition

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Faecal Microbiota Composition in Adults Is Associated with the FUT2 Gene Determining the Secretor Status

The human intestine is colonised with highly diverse and individually defined microbiota, which likely has an impact on the host well-being. Drivers of the individual variation in the microbiota compositions are multifactorial and include environmental, host and dietary factors. We studied the impact of the host secretor status, encoded by fucosyltransferase 2 (FUT2) -gene, on the intestinal mi...

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Mothers Secretor Status Affects Development of Childrens Microbiota Composition and Function: A Pilot Study

BACKGROUND One mechanism by which early life environment may influence long term health is through modulation of the gut microbiota. It is widely accepted that the optimal source of nutrition in early life is breast milk, with Human Milk Oligosaccharides (HMOs) thought to play an important role in nourishing the developing microbiota. However, mothers with inactive secretor genes have altered H...

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Secretor status and caries.

Prediction of dental caries in pre-school children. Caries Res 1993; 27: 424–430). In these two papers, I was able to show a lower level of dental caries and a higher level of being caries free among the group that were non-secretors. This fits in well with the findings in the study of Kárpati from 2014. This work was carried out on children aged 4–6 years and included deciduous and newly erupt...

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Relevance of secretor status genotype and microbiota composition in susceptibility to rotavirus and norovirus infections in humans

Host genetic factors, such as histo-blood group antigens (HBGAs), are associated with susceptibility to norovirus (NoV) and rotavirus (RV) infections. Recent advances point to the gut microbiome as a key player necessary for a viral pathogen to cause infection. In vitro NoV attachment to host cells and resulting infections have been linked to interactions with certain bacterial types in the gut...

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Secretor status in asthma and hay fever.

The observation that ABO agglutinins are present in a wide variety of pollens (Denborough, 1964) and so must commonly be inhaled, and the knowledge that plant agglutinins are antigenic (Mikela, 1957), prompted us to study secretor status in allergic disease of the respiratory tract, namely in asthma and hay fever. The opportunity has been taken to measure the amount of isoagglutinins present in...

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ژورنال

عنوان ژورنال: American Journal of Obstetrics and Gynecology

سال: 2018

ISSN: 0002-9378

DOI: 10.1016/j.ajog.2017.10.212