301. LONG TERM RESULTS OF SINGLE AND MULTI-INCISION MINIMALLY INVASIVE ESOPHAGECTOMY (MIE) FOR TREATING ESOPHAGEAL CANCER: A PROPENSITY SCORE MATCHED STUDY

Abstract Minimally invasive esophagectomy (MIE) is widely accepted as the standard treatment for esophageal cancer. It provides similar oncological outcomes with less pain and morbidity compared to open surgery. We first described MIE single-incision both in laparoscopic thoracoscopic phase 2015. Compared multi-portal approach, short-term result showed comparable perioperative outcome significantly reduced after With accumulated clinical experience, we our long-term follow-up versus multi-incision MIE. Patients cancer, receiving at institute from 2008 2022 were included. 337 patients underwent MIE, while 467 received Matching based on propensity scores produced 290 each group. The baseline characteristics between two groups matching. Overall survival (OS) progression free (PFS) not compromised multiple-incision (5-year OS: 42.9% vs. 21.2%, p < 0.001; 5-year PFS: 35.1% 17.1%, 0.001). operation time was shorter (505.7 min 562.4 min, Single-incision had larger mean number of dissected lymph nodes (45.6 vs 37.4, There no significant differences terms complications (single multi: 20.3% 15.9%, = 0.196) R1/2 rate 11.5% 9.0%, 0.340). safe, feasible effective Its are when its approach. Three-dimensional imaging may play a role higher quality resection more lymphatic clearance