356 Minocycline inhibits keratinocyte proliferation via modulating Ca2+/lysosome/IL1α system
نویسندگان
چکیده
منابع مشابه
Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells.
BACKGROUND Mineral Pitch (MP) is a dark brown coloured humic matter originating from high altitude rocks. It is an Ayurvedic medicinal food, commonly used by the people of the Himalayan regions of Nepal and India for various body ailments. METHODS The Huh-7 cells were treated with different concentrations of MP for 24 h, and both apoptosis and proliferation was determined by the TUNEL and MTT...
متن کاملGAS5 Inhibits Gastric Cancer Cell Proliferation Partly by Modulating CDK6.
INTRODUCTION As it is not clear whether growth arrest-specific 5 (GAS5) inhibits gastric cancer (GC) cell proliferation by regulating cell cycle, we analyzed the effect of GAS5 on cell cycle regulation of GC cells and explored the underlying mechanism. METHODS We measured GAS5 levels in GC tissues and corresponding normal tissues, and analyzed the role of GAS5 in regulation of cell proliferat...
متن کاملFibrin Stimulates Keratinocyte Proliferation
Received February 9, 2005; revision accepted for publication June 21, 2005. Correspondence: Misa Yamamoto, MT (Medical Technologist), CT (Cytologist), Faculty of Health Sciences, Yamaguchi University School of Medicine, MinamiKogushi 1-1-1, Ube, Yamaguchi, 755-8554, Japan. e-mail: [email protected] Fibrin Stimulates the Proliferation of Human Keratinocytes through the Autocrine Mechani...
متن کامل14-3-3σ regulates keratinocyte proliferation and differentiation by modulating Yap1 cellular localization
The homozygous repeated epilation (Er/Er) mouse mutant of the gene encoding 14-3-3σ displays an epidermal phenotype characterized by hyperproliferative keratinocytes and undifferentiated epidermis. Heterozygous Er/+ mice develop spontaneous skin tumors and are highly sensitive to tumor-promoting 7,12-dimethylbenzanthracene/12-O-tetradecanoyl-phorbol-13-acetate induction. The molecular mechanism...
متن کاملOsthole inhibits histamine-dependent itch via modulating TRPV1 activity
Osthole, an active coumarin isolated from Cnidium monnieri (L.) Cusson, has long been used in China as an antipruritic herbal medicine; however, the antipruitic mechanism of osthole is unknown. We studied the molecular mechanism of osthole in histamine-dependent itch by behavioral test, Ca(2+) imaging, and electrophysiological experiments. First, osthole clearly remitted the scratching behavior...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.03.432