38 Small molecule inhibitors of BAF; a new family of compounds in HIV-1 latency reversal
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چکیده
منابع مشابه
Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal
Persistence of latently infected cells in presence of Anti-Retroviral Therapy presents the main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds capable of HIV-1 latency reversal in order to render infected cells susceptible to viral cytopathic effects and immune clearance. We identified the BAF chromatin remodeling complex as a key player required for ma...
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15 صفحه اولThe BAF complex and HIV latency
The persistence of a reservoir of transcriptionally competent but latent virus in the presence of antiviral regimens presents the main impediment to a curative therapy against HIV. Therefore it is critical to understand the molecular mechanisms, which lead to the establishment and maintenance of HIV latency, and which contribute to the reversal of this process and mediate HIV transcriptional ac...
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ژورنال
عنوان ژورنال: Journal of Virus Eradication
سال: 2016
ISSN: 2055-6640
DOI: 10.1016/s2055-6640(20)30983-3