3D‐Printed Synthetic Hydroxyapatite Scaffold With In Silico Optimized Macrostructure Enhances Bone Formation In Vivo

3D printing technologies are a promising approach to treat intra-oral bone defects, especially those with poor regenerative potential. However, there is lack of evidence regarding the impact internal design specifications on Here, an in silico optimize calcium phosphate-based scaffolds for regeneration proposed. Based model neotissue formation, gyroid 3D-printed scaffold designed and manufactured using UV stereolithography bioceramic materials. An orthogonal lattice structure particulate xenograft used as control groups. The implanted subperiosteally under shell rat calvarium 4 or 8 weeks neoformation performances investigated by nanofocus computed tomography decalcified histology. After weeks, group associated higher ingrowth potential characterized signs osteoinduction (newly formed islands). material contact similar between present results reinforce this modeling strategy experimental architecture seems be highly applications.