4-Amino-2-chlorophenol: Comparative in vitro nephrotoxicity and mechanisms of bioactivation
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چکیده
منابع مشابه
Synthesis and in vitro Antibacterial Activity of Some Novel 2-Amino-4, 6-D Derivatives
Heterocyclic systems are one of the most important classes of organic compounds present in nature or synthesized in laboratory. These compounds posses an array of biological activities and are employed in the treatment of commonly occurring diseases. Keeping this in view, some new 2-amino-4,6-diarylpyrimidine from chalcones were synthesized. Eight novel 2-amino-4,6-diarylpyrimidine derivatives ...
متن کاملOral carcinogenicity and toxicity of 2-amino-4-chlorophenol in rats.
OBJECTIVES This study was carried out to clarify the subchronic and chronic toxicity, and carcinogenicity of 2-amino-4-chlorophenol(ACP). METHODS Carcinogenicity, and chronic and subchronic toxicity of ACP were examined by feeding 10 rats of both sexes ACP-containing diet at a dose level of 0 (control), 512, 1,280, 3,200, 8,000 or 20,000 ppm (w/w) for 13 wk and 50 rats of both sexes at a dose...
متن کاملSpectrophotometric Determination of 2- Amino- 4- Chlorophenol as a Potential Impurity in Chlorzoxazone Bulk Drug
2-amino-4-chlorophenol (ACP) is a synthetic precursor of the skeletal muscle relaxant; chlorzoxazone. A rapid simple colorimetric method was proposed for the determination of 2amino-4-chlorophenol as a potential impurity in chlorzoxazone bulk powder via its reaction with 4-aminoantipyrine in presence of alkaline oxidizing agent (K3[Fe(CN)6] / NH3) and measuring the produced red color at 520 nm....
متن کاملPhotocatalytic Degradation of 4-Chlorophenol. 2. The 4-Chlorocatechol Pathway
The TiO2-mediated photocatalytic degradation of 4-chlorocatechol is studied as a branch of the degradation of 4-chlorophenol. In addition to some basic kinetic studies, the identities of many of the cyclic and acyclic intermediates, verified in most cases with authentic samples, are reported. From 4-chlorocatechol, the major product is hydroxylation to form 5-chloro-1,2,4-benzenetriol. A small ...
متن کاملsynthesis and in vitro antibacterial activity of some novel 2-amino-4, 6-d derivatives
heterocyclic systems are one of the most important classes of organic compounds present in nature or synthesized in laboratory. these compounds posses an array of biological activities and are employed in the treatment of commonly occurring diseases. keeping this in view, some new 2-amino-4,6-diarylpyrimidine from chalcones were synthesized. eight novel 2-amino-4,6-diarylpyrimidine derivatives ...
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ژورنال
عنوان ژورنال: Chemico-Biological Interactions
سال: 2014
ISSN: 0009-2797
DOI: 10.1016/j.cbi.2014.10.001