5′-Halogenated analogs of oxymorphindole
نویسندگان
چکیده
منابع مشابه
Morphogenic effects of halogenated thymidine analogs on Drosophila. II. Incorporation of 5 -bromodeoxyuridine into DNA.
When 5-bromodeoxyuridine is fed to Drosophila larvae, a variety of morphogenic lesions are found in the hatching adults. Experiments were undertaken to determine whether 5-bromodeoxyuridine is incorporated into Drosophila DNA under the conditions which induce developmental modifications. Radioautographic techniques were used to examine the distribution of [aH lbromodeoxyuridine in Drosophila la...
متن کاملCapacity of deoxycytidine to selectively antagonize cytotoxicity of 5-halogenated analogs of deoxycytidine without loss of antiherpetic activity.
Enzyme kinetic studies from this laboratory (M. Dobersen and S. Greer, Biochemistry 17:920-928, 1978) suggested that deoxycytidine could antagonize the toxicity of 5-halogenated analogs of deoxycytidine without interfering with their antiviral activity. Antagonism by deoxycytidine of the toxicity of 5-chlorodeoxycytidine without impairing its anti-herpes simplex virus type 2 activity is demonst...
متن کاملPeroxisome Proliferator-Activated Receptor γ Is a Target for Halogenated Analogs of Bisphenol A
BACKGROUND The occurrence of halogenated analogs of the xenoestrogen bisphenol A (BPA) has been recently demonstrated both in environmental and human samples. These analogs include brominated [e.g., tetrabromobisphenol A (TBBPA)] and chlorinated [e.g., tetrachlorobisphenol A (TCBPA)] bisphenols, which are both flame retardants. Because of their structural homology with BPA, such chemicals are c...
متن کاملThe determination of GC-MS relative molar responses of some n-alkanes and their halogenated analogs.
The dependence of relative response factors on the carbon atom number related to naphthalene has been investigated in homologous series by using gas chromatography-mass spectrometry. Relative responses of some straight chain aliphatic n-alkanes and their halogenated derivatives (chlorine, bromine and iodine) were compared in the experiments. Linear correlations were found between the molecular ...
متن کاملNovel trypanocidal analogs of 5'-(methylthio)-adenosine.
The purine nucleoside 5'-deoxy-5'-(hydroxyethylthio)-adenosine (HETA) is an analog of the polyamine pathway metabolite 5'-deoxy-5'-(methylthio)-adenosine (MTA). HETA is a lead structure for the ongoing development of selectively targeted trypanocidal agents. Thirteen novel HETA analogs were synthesized and examined for their in vitro trypanocidal activities against bloodstream forms of Trypanos...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2007
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2007.07.098