55. Regional cerebral blood flow (rCBF) measurement and the clinical application using Patlak Plot method with 99mTc-HMPAO

Usefulness of an Automatic Quantitative Method for Measuring Regional Cerebral Blood Flow Using 99mTc Ethyl Cysteinate Dimer Brain Uptake Ratio

 Objective(s): Improved brain uptake ratio (IBUR), employing 99mTc-ethyl cysteinate dimer (99mTc-ECD), is an automatic non-invasive method for quantitatively measuring regional cerebral blood flow (rCBF). This method was developed by the reconstruction of the theory and linear regression equation, based on rCBF measurement by H215O positron emission tomography. Clarification of differences in r...

Regional cerebral blood flow (rCBF) and cerebral vasoreactivity in patients with retinal ischaemic symptoms.

Regional cerebral blood flow (rCBF) and cerebral vasoreactivity were assessed in 28 consecutive patients who presented with retinal ischaemic symptoms, without clinical or cerebral CT evidence of cerebral ischaemia. rCBF was measured using xenon-133 inhalation and single photon emission computed tomography before and 20 minutes after the intravenous administration of 1 g acetazolamide. The find...

Cerebral complications following measurements of regional cerebral blood flow (rCBF) with the intra-arterial 133Xenon injection method.

Improved Method for Noninvasive Measurement of Regional Cerebral Blood Flow

A clinical method for noninvasive measurement of regional cerebral blood flow (rCBF) and blood volume (rCBV) is described, based on Obrist's 10 minute, desaturation method after 1 minute inhalation of Xe. Sixteen collimated probes are placed over both hemispheres and brain stem-cerebellar regions. End-tidal Xe curves are used for correction of recirculation. KEV discriminators are set to record...

Preparation and labeling of HMPAO kit in Iran [Persian]

In recent years, several radiopharmaceuticals have been developed for imaging regional cerebral blood flow (rCBF) such as 75Se labelled PIPSE and MOSE, ²º¹TI labelled DDC and 99mTc labelled HMPAO. HMPAO with two asymmetric carbon atoms (At the 3 and 9 positions), produces d,1 and meso isomers, only one of which is retained in the brain. Rapid intracellular conversion of 99mTc-d,1-HMPAO to...