#6881 ELEVATED LEVELS OF THE C5B9 TERMINAL COMPLEMENT COMPLEX IN PATIENTS RECEIVING RENAL REPLACEMENT THERAPY

Abstract Background and Aims The complement cascade its inhibitors play an important role in health disease. Complement activation represents a key pathogenic mechanism underlying inflammatory diseases affecting the kidney. study aimed to investigate C5b9 system renal biopsies, where we stained all obtained kidney biopsies from year 2017 (n = 256). Method Antibody staining against terminal was performed, score for each glomerulus 1942) generated based on automated image analysis. Mean scores interstitium, tubules blood vessels, whole biopsy sections were also calculated. Results Globally segmentally, sclerosed areas glomeruli much stronger than their non-sclerosed glomerular counterparts. results linked with Renal Replacement Therapy (RRT) status clinical data Norwegian Kidney Biopsy Registry. study's main findings that elevated levels of present patients RRT glomeruli, vessels section staining. Fibrillar glomerulopathy Membranous Glomerulonephritis had highest scores, while Hypertensive Nephrosclerosis represented low score. correlated weakly or non-significantly variables like age, pressure eGFR. degree fibrosis showed associated positive correlation C5b-9 intensities. Additionally, (from 50th percentile above) significantly risk receiving within 60 months biopsy. Conclusion sclerotic as well RRT. A weak between function suggest may be independent effector CKD.