A biological function for glucagon-like peptide-2
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چکیده
منابع مشابه
A biological function for glucagon-like peptide-2.
The cloning of the glucagon gene from anglerfish, rodents and humans ((1) and references therein) in the early 1980s yielded the surprising finding that the glucagon gene not only encoded the known peptide hormone glucagon, but also contained sequences for two additional peptides, which, because of their homology to glucagon, were named glucagon-like peptide (GLP)-1 and -2 (Fig. 1). The protein...
متن کاملGlucagon-like Peptide-2.
Multiple peptide hormones produced within the gastrointestinal system aid in the regulation of energy homeostasis and metabolism. Among these is the intestinotrophic peptide glucagon-like peptide-2 (GLP-2), which is released following food intake and plays a significant role in the adaptive regulation of bowel mass and mucosal integrity. The discovery of GLP-2's potent growth-promoting and cyto...
متن کاملThe glucagon-like Peptide-2
Multiple peptide hormones produced within the gastrointestinal system act also in the central nervous system and aid in the regulation of energy homeostasis and metabolism. The list of these peptides is progressively increasing and includes glucagon-like peptide 2 (GLP-2) as an anorexigenic factor. GLP-2 is released from enteroendocrine L-cells following food intake and its principal target is ...
متن کاملHOT TOPIC Glucagon-Like Peptide 2*
Glucagon-like peptide 2 (GLP-2) is a 33 amino acid peptide-encoded carboxyterminal to the sequence of GLP-1 in the proglucagon gene. Both GLP-1 and GLP-2 are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms of action. GLP-2 regulates gastric motility, gastric acid secretion, intestinal hexose transport, and increases the barrier function of the gut e...
متن کاملGlucagon-like peptide 2: an update
Purpose of review Glucagon-like peptide 2 (GLP-2) is a 33-amino acid peptide secreted in a nutrient-dependent manner from gut enteroendocrine cells. The proliferative and antiapoptotic actions of GLP-2 lead to expansion of the mucosal surface area and enhanced capacity for nutrient absorption in multiple models of experimental intestinal injury. These findings have raised the possibility that G...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 1998
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje.0.1390265