A chromatography-free and aqueous waste-free process for thioamide preparation with Lawesson’s reagent

Chromatography-free recovery of biopharmaceuticals through aqueous two-phase processing.

The therapeutic use of proteins has created an increasing demand for feasible and economical methods for both up- and downstream processes. However, whereas upstream processes have attracted substantial investment and commercial attention, downstream processing has been overlooked, causing a production bottleneck that is shifting the costs of production. This review focuses on the use of aqueou...

Aqueous preparation of surfactant-free copper selenide nanowires.

Uniform surfactant-free copper selenide (Cu2-xSe) nanowires were prepared via an aqueous route. The effects of reaction parameters such as Cu/Se precursor ratio, Se/NaOH ratio, and reaction time on the formation of nanowires were comprehensively investigated. The results show that Cu2-xSe nanowires were formed through the assembling of CuSe nanoplates, accompanied by their self-redox reactions....

Determination of Sulfate and Sulfamate in Topiramate Using a Reagent-Free Ion Chromatography System

Introduction Epilepsy is a common neurological disorder that can cause anywhere from a brief cessation of responsiveness to severe muscle spasms with a loss of consciousness.1 This condition is usually controlled with antiepileptic drugs (AEDs). However, approximately 20% of patients with epilepsy are resistant to therapy with first-generation AEDs.2 Topiramate (Topamax®) is a second-generation...

p-Toluenesulfonic acid a useful and selective reagent for the oxidation of benzoins to benziles under solvent-free condition

Oxidation of some benzoins to benziles is reported by using p-toluenesulfonic acid as aselective oxidation catalyst under solvent-free condition in high yield. The adjacent carbonylgroup is necessary for the oxidation of hydroxyl group in these compounds. The reaction iscarried out in a sand-bath at 100 °C with minimum by-products.

Determination of N-Methylpyrrolidine in Cefepime Using a Reagent-Free Ion Chromatography System