A Conjugated Linoleic Acid Supplement Containing Trans-10, Cis-12 Conjugated Linoleic Acid Reduces Milk Fat Synthesis in Lactating Goats

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Trans-10, cis-12 Conjugated Linoleic Acid

Conjugated linoleic acids (CLA) are a group of linoleic acid isomers having double bonds in conjugated position, i. e. the double bonds are separated by one single bond. Two of the isomers: cis-9, trans-11 (c9, t11) and trans-10, cis-12 (t10, c12) CLA, have been shown to have biologically interesting properties. The c9, t11 CLA has been reported to have anticancer, antidiabetic and anti-inflamm...

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A supplement containing trans-10, cis-12 conjugated linoleic acid reduces milk fat yield but does not alter organ weight or body fat deposition in lactating ewes.

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Trans-10, cis-12 conjugated linoleic acid decreases de novo lipid synthesis in human adipocytes.

Conjugated linoleic acid (CLA) reduces adiposity in vivo. However, mechanisms mediating these changes are unclear. Therefore, we treated cultures of human adipocytes with trans-10, cis-12 (10,12) CLA, cis-9, trans-11 (9,11) CLA or other trans fatty acids (FA), and measured indices of lipid metabolism. The lipid-lowering effects of 10,12 CLA were unique, as other trans FA did not reduce TG conte...

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De novo synthesis of trans-10, cis-12 conjugated linoleic acid in oleaginous yeast Yarrowia Lipolytica

BACKGROUND Conjugated linoleic acid (CLA) has many well-documented beneficial physiological effects. Due to the insufficient natural supply of CLA and low specificity of chemically produced CLA, an effective and isomer-specific production process is required for medicinal and nutritional purposes. RESULTS The linoleic acid isomerase gene from Propionibacterium acnes was expressed in Yarrowia ...

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Trans-10, cis-12 conjugated linoleic acid increases fatty acid oxidation in 3T3-L1 preadipocytes.

The purpose of this study was to examine the effect of 0-50 micromol/L trans-10, cis-12 conjugated linoleic acid (CLA) and cis-9, trans-11 CLA isomers on lipid and glucose metabolism in cultures of differentiating 3T3-L1 preadipocytes. Specifically, we investigated the effects of 6 d of CLA treatment on the following: 1) (14)C-glucose and (14)C-oleic acid incorporation and esterification into l...

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ژورنال

عنوان ژورنال: Journal of Dairy Science

سال: 2008

ISSN: 0022-0302

DOI: 10.3168/jds.2008-1071