A Conversation on Protein Folding
نویسندگان
چکیده
منابع مشابه
Protein Stability, Folding, Disaggregation and Etiology of Conformational Malfunctions
Estimation of protein stability is important for many reasons: first providing an understanding of the basic thermodynamics of the process of folding, protein engineering, and protein stability plays important role in biotechnology especially in food and protein drug design. Today, proteins are used in many branches, including industrial processes, pharmaceutical industry, and medical fields. A...
متن کاملTheoretical perspectives on protein folding.
Understanding how monomeric proteins fold under in vitro conditions is crucial to describing their functions in the cellular context. Significant advances in theory and experiments have resulted in a conceptual framework for describing the folding mechanisms of globular proteins. The sizes of proteins in the denatured and folded states, cooperativity of the folding transition, dispersions in th...
متن کاملProtein folding on the ribosome.
In living systems, polypeptide chains are synthesised on ribosomes, molecular machines composed of over 50 protein and nucleic acid molecules. As nascent chains emerge from the ribosomal exit tunnel and into the cellular environment, the majority must fold into specific structures in order to function. In this article we discuss recent approaches designed to reveal how such folding occurs and r...
متن کاملShedding light on protein folding
hen endothelial cells adhere to the extracellular matrix protein fibronectin, they can proliferate in response to growth factors. Adhesion to laminin, however, brings their cell cycles to a dead stop. Why? Given that the response depends on the composition of the extracellular matrix, Filippo Giancotti and his colleagues at the Memorial Sloan-Kettering Cancer Center (New York, NY) proposed in 1...
متن کاملFolding a protein in a computer: an atomic description of the folding/unfolding of protein A.
We study the folding mechanism of a three-helix bundle protein at atomic resolution, including effects of explicit water. Using replica exchange molecular dynamics we perform enough sampling over a wide range of temperatures to obtain the free energy, entropy, and enthalpy surfaces as a function of structural reaction coordinates. Simulations were started from different configurations covering ...
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ژورنال
عنوان ژورنال: Journal of Biomolecular Structure and Dynamics
سال: 2011
ISSN: 0739-1102,1538-0254
DOI: 10.1080/073911011010524955