A deletion encompassing Zic3 in Bent tail, a mouse model for X-linked neural tube defects
نویسندگان
چکیده
منابع مشابه
The X-linked mouse mutation Bent tail is associated with a deletion of the Zic3 locus.
Bent tail (BN:) is a spontaneous, semi-dominant mutation on the mouse X chromosome that produces tail deformities and, rarely, open neural tube defects. Analysis of 292 normal male and affected male and female progeny from an intraspecific back-cross involving BN: supports a gene order of cen-DXMit89-18.5 +/- 2.3 cM-DXMit166-1.4 +/- 0.7 cM-BN:-1.0 +/- 0.6 cM-DXMit140 -4.8 +/- 1.3 cM-DXBay6-tel....
متن کامل"Bent-Tail," A Dominant, Sex-Linked Mutation in the Mouse.
Although sex-linkage in animals is no longer an unusual phenomenon, its apparent rarity in rodents is noteworthy, especially in the intensively studied house mouse and rat. Hauschka, et al.,1 have presented evidence for a sex-linked lethal altering the sex ratio in the house mouse; Falconer2 recently reported a second sex-linked mutation in the house mouse. A third sex-linked mutation, Bent-tai...
متن کاملMouse models for neural tube closure defects.
Neural tube closure defects (NTDs), in particular anencephaly and spina bifida, are common human birth defects (1 in 1000), their genetics is complex and their risk is reduced by periconceptional maternal folic acid supplementation. There are > 60 mouse mutants and strains with NTDs, many reported within the past 2 years. Not only are NTD mutations at loci widely heterogeneous in function, but ...
متن کاملA mouse model for X-linked adrenoleukodystrophy.
X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder with impaired beta-oxidation of very long chain fatty acids (VLCFAs) and reduced function of peroxisomal very long chain fatty acyl-CoA synthetase (VLCS) that leads to severe and progressive neurological disability. The X-ALD gene, identified by positional cloning, encodes a peroxisomal membrane protein (adrenoleukodystrophy protei...
متن کاملCrooked tail (Cd) models human folate-responsive neural tube defects.
Genetic correlation of human neural tube defects (NTDs) with NTD genes identified in mouse may unravel predisposing complex traits for assessment of individual risk and treatment in clinical settings. Folic acid (FA) can reduce the recurrence of NTDs in human populations by as much as 50-70%, though the mechanism of this rescue is unknown. We examined whether Crooked tail ( Cd ), a mouse strain...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2000
ISSN: 1460-2083
DOI: 10.1093/hmg/9.11.1615