A Framework for Globally Optimizing Mixed-Integer Signomial Programs
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This paper is motivated by the fact that mixed integer nonlinear programming is an important and difficult area for which there is a need for developing new methods and software for solving large-scale problems. Moreover, both fundamental building blocks, namely mixed integer lin
A major challenge in computational peptide and protein design is the systematic generation of novel peptides and proteins which are either compatible with existing target template structures or with arbitrarily postulated new three dimensional structural folds. In this paper, an